Caroline Diorio

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche sur le cancer

Financements des 2 dernières années

• Antoine Rioux, Maîtrise en épidémiologie - épidémiologie clinique - avec mémoire
• Farah Ben Souilah, Doctorat en épidémiologie
• Jacques Yonhosu Singbo Sagbohan, Maîtrise en épidémiologie - avec mémoire
• Juliette Bherer, Doctorat en médecine moléculaire
• Kaoutar Ennour-Idrissi, Doctorat en épidémiologie
• Laurence Poirier, Maîtrise en épidémiologie - épidémiologie clinique - avec mémoire
• Ouafa Badre, Doctorat en épidémiologie

Encadrements des 5 dernières années

• Alisson Clemenceau, Doctorat en médecine moléculaire
• Anna Burguin, Doctorat en médecine moléculaire
• Codjo Djignéfa Djade, Doctorat en épidémiologie
• Dzevahira Dzevka Dragic, Doctorat en épidémiologie
• Farida Hamidou Farida Hamidou, Maîtrise en médecine moléculaire - avec mémoire
• Juliette Bherer, Maîtrise en médecine moléculaire - avec mémoire
• Mamady Magassouba, Maîtrise en biostatistique - avec mémoire
• Thibaut Nathan T Rommel, Maîtrise en médecine moléculaire - avec mémoire

Travaux de recherche des 5 dernières années

Mammary Adipocyte Size, Obesity-Related Breast Adipose Tissue Dysfunction, and Breast Cancer: A Systematic Review and Meta-Analysis Cancers, 2026. Ouafa Badre, Sue-Ling Chang, Belkacem Abdous, Julie Lemieux, Francine Durocher, André Tchernof, Caroline Diorio. DOI 10.3390/cancers18152464

Empirically derived dietary patterns and prostate cancer risk: a systematic review and meta-analysis of prospective cohorts European Journal of Cancer Prevention, 2026. Farah Ben Souilah, Roxane Tourigny, Jean-Philippe Drouin-Chartier, Caroline Diorio, Vincent Fradet. DOI 10.1097/cej.0000000000001014

Clinical and prognostic significance of parathyroid hormone-related protein in breast cancer: a systematic review and meta-analyses of observational studies in women Endocrine-Related Cancer, 2026. Alisson Clemenceau, Juliette Bherer, Alyssa Grimshaw, Francine Durocher, Caroline Diorio, John J Wysolmerski. DOI 10.1530/erc-25-0324

FOXA1 and RAB25 as Biomarkers of Breast Cancer Cell Response to CYP1A1-Activated Prodrugs: Insights from CEU-938 Pharmaceuticals, 2026. Quentin Bruxelles, Geneviève Hamel-Côté, Marie-Pier Scott-Boyer, Vincent Ouellette, René C.-Gaudreault, Francine Durocher, Caroline Diorio, Arnaud Droit, Sébastien Fortin. DOI 10.3390/ph19030357

Bazedoxifene and Beyond: Identifying This SERM’s Targets and Deciphering Its Molecular Mechanisms Advances in Pharmacological and Pharmaceutical Sciences, 2026. Juliette Bherer, Alisson Clemenceau, Caroline Diorio, Francine Durocher. DOI 10.1155/adpp/3028716

Factors influencing traditional adiposity indicators and mammary adipocyte size in women with breast cancer International Journal of Obesity, 2025. Kaoutar Ennour-Idrissi, Sofia Laforest, André Tchernof, Francine Durocher, Caroline Diorio. DOI 10.1038/s41366-025-01814-5

Rakaia: interactive discovery of spatial biology at scale 2025. Matthew Watson, Golnaz Abazari, Edward L.Y. Chen, Tiak Ju Tan, Jennifer L. Gorman, Caroline Diorio, Hal K. Berman, Kieran R. Campbell, Hartland W. Jackson. DOI 10.1101/2025.08.15.670550

Using Machine Learning to Improve Control for Confounding in the Dynamic Weighted Ordinary Least Squares Estimator of Optimal Adaptive Treatment Strategies Biometrical Journal, 2025. Kossi Clément Trenou, Miceline Mésidor, Aida Eslami, Hermann Nabi, Caroline Diorio, Denis Talbot. DOI 10.1002/bimj.70068

Alcohol consumption and DNA methylation: an epigenome-wide association study within the French E3N cohort Clinical Epigenetics, 2025. Dzevka Dragic, Fanny Artaud, Mojgan Karimi, Thérèse Truong, Laura Baglietto, Jean-François Deleuze, Caroline Diorio, Gianluca Severi. DOI 10.1186/s13148-025-01893-1

An examination of acrylamide and cadmium as possible mediators of the association between cigarette smoking and chronic musculoskeletal pain Pain, 2025. Codjo Djignefa Djade, Caroline Diorio, Danielle Laurin, Denis Talbot, Pierre-Hugues Carmichael, Clermont E. Dionne. DOI 10.1097/j.pain.0000000000003517

Reply to Zeng and Zhou Pain, 2025. Codjo Djignefa Djade, Caroline Diorio, Danielle Laurin, Denis Talbot, Pierre-Hugues Carmichael, Clermont E. Dionne. DOI 10.1097/j.pain.0000000000003610

First versus second-generation molecular profiling tests: How both can guide decision-making in early-stage hormone-receptor positive breast cancers? Cancer Treatment Reviews, 2025. Flora Nguyen Van Long, Brigitte Poirier, Christine Desbiens, Marjorie Perron, Claudie Paquet, Cathie Ouellet, Caroline Diorio, Julie Lemieux, Hermann Nabi. DOI 10.1016/j.ctrv.2025.102909

The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative Cancer Cell, 2025. Tess Aalto, Maria Abacan, Shirin Abadi, Farnoosh Abbas Aghababazadeh, Zeinab Abbaszadeh, Mahmoud Abdelsalam, Albiruni Abdul Razak, Safa Abdulsalam, Dor David Abelman, Armita Abolghasemi, Anju Abraham, Rohan Abraham, Behram C. Acar, Adriana Aguilar-Mahecha, Mozhdeh Ahanfeshar-Adams, Sinead Aherne, Zohreh Ahmadi, Syed A.K. Shifat Ahmed, Laurie Ailles, Yelena Aizenberg, Mohammad Reza Akbari, Vahid Akbari, Azarm Akhavien, Rima Al Bati, Rima Al-Awar, Dhuha Al-Sajee, Afnan Al-Saleh, Akinola A. Alafiatayo, Aqsa Alam, Roula Albadine, Alexandria Albano, Waleed Alduaij, Helmi Alfarra, Rached Alkallas, Eric P. Allain, Hayley Alloway, Adrian Ally, Khadijah Alshankati, Eitan Amir, Jianghong An, Colleen Anderson, Deborah Anderson, Helen Anderson, Nerkeza Andjelic, Irene Andrulis, Tomohiro Aoki, Samuel Aparicio, Armen Aprikian, Srivastava Archana, Linlea Armstrong, Thomas Arnason. DOI 10.1016/j.ccell.2025.03.014

Feasibility and acceptability of a personalised primary prevention strategy for women and men at high risk of breast and prostate cancer: the 3PC study protocol for a pilot randomised controlled trial BMJ Open, 2025. Intissar Souli, Julie Lapointe, Kinsley-Marlie Jura, Jocelyne Chiquette, Michel Dorval, Caroline Diorio, Sophie Lauzier, Étienne Audet-Walsh, Steve Bilodeau, Madeleine Côté, Carmen Brisson, Nelson Charette, Philippe Fortier, Jean-Sébastien Paquette, Yves Fradet, Josée Savard, Vincent Fradet, Hermann Nabi. DOI 10.1136/bmjopen-2024-085255

Biological Markers of Musculoskeletal Pain: A Scoping Review Journal of Pain Research, 2024. Codjo Djignefa Djade, Caroline Diorio, Danielle Laurin, Septime Pepin Hector Hessou, Alfred Kodjo Toi, Amédé Gogovor, Aboubacar Sidibe, Giraud Ekanmian, Teegwendé Valérie Porgo, Hervé Tchala Vignon Zomahoun, Clermont E Dionne. DOI 10.2147/jpr.s472934

A characterization of mitotic and centrosomal defects in a continuum model of Breast Cancer 2024. Alexsandro dos Santos, Caroline Diorio, Francine Durocher, Sabine Elowe. DOI 10.1101/2024.09.20.614099

Analyse des effets des inhibiteurs de l’aromatase en traitement prolongé chez les femmes ménopausées atteintes d’un cancer du sein non métastatique hormonodépendant ayant déjà reçu cinq ans d’hormonothérapie adjuvante : revue systématique et méta-analyse Bulletin du Cancer, 2024. Kossi Clément Trenou, Miceline Mésidor, Caroline Diorio, Aida Eslami, Denis Talbot. DOI 10.1016/j.bulcan.2023.12.016

Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary Lipids in Health and Disease, 2024. Emilie Wong Chong, France-Hélène Joncas, Pierre Douville, Dimcho Bachvarov, Caroline Diorio, Frédéric Calon, Ann-Charlotte Bergeron, Jonatan Blais, Shuk On Annie Leung, Nabil Georges Seidah, Anne Gangloff. DOI 10.1186/s12944-024-02038-8

BRCA1 Promoter Hypermethylation in Malignant Breast Tumors and in the Histologically Normal Adjacent Tissues to the Tumors: Exploring Its Potential as a Biomarker and Its Clinical Significance in a Translational Approach Genes, 2023. Yassire Oubaddou, Mohamed Oukabli, Salma Fenniche, Abderrahim Elktaibi, Mohamed Reda Elochi, Abderrahmane Al Bouzidi, Zineb Qmichou, Nadia Dakka, Caroline Diorio, Antje Richter, Youssef Bakri, Rabii Ameziane El Hassani. DOI 10.3390/genes14091680

Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments Journal of Clinical Medicine, 2023. Anna Burguin, Jenny Roy, Geneviève Ouellette, René Maltais, Juliette Bherer, Caroline Diorio, Donald Poirier, Francine Durocher. DOI 10.3390/jcm12134241

Role of Secreted Frizzled-Related Protein 1 in Early Breast Carcinogenesis and Breast Cancer Aggressiveness Cancers, 2023. Alisson Clemenceau, Aurélie Lacouture, Juliette Bherer, Geneviève Ouellette, Annick Michaud, Étienne Audet-Walsh, Caroline Diorio, Francine Durocher. DOI 10.3390/cancers15082251

Work-Related Psychosocial Factors and Global Cognitive Function: Are Telomere Length and Low-Grade Inflammation Potential Mediators of This Association? International Journal of Environmental Research and Public Health, 2023. Caroline S. Duchaine, Chantal Brisson, Caroline Diorio, Denis Talbot, Elizabeth Maunsell, Pierre-Hugues Carmichael, Yves Giguère, Mahée Gilbert-Ouimet, Xavier Trudel, Ruth Ndjaboué, Michel Vézina, Alain Milot, Benoît Mâsse, Clermont E. Dionne, Danielle Laurin. DOI 10.3390/ijerph20064929

Effects of Concentrated Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation on Quality of Life after Radical Prostatectomy: A Phase II Randomized Placebo-Controlled Trial (RCT-EPA) Nutrients, 2023. Hanane Moussa, Karine Robitaille, Jean-François Pelletier, Roxane Tourigny, Yves Fradet, Louis Lacombe, Paul Toren, Michele Lodde, Rabi Tiguert, Thierry Dujardin, Yves Caumartin, Thierry Duchesne, Pierre Julien, Josée Savard, Caroline Diorio, Vincent Fradet. DOI 10.3390/nu15061369

Double robust estimation of optimal partially adaptive treatment strategies: An application to breast cancer treatment using hormonal therapy Statistics in Medicine, 2023. Denis Talbot, Erica E.M. Moodie, Caroline Diorio. DOI 10.1002/sim.9608

Association between vitamin D and calcium intakes, breast microcalcifications, breast tissue age-related lobular involution and breast density Menopause, 2022. Alisson Clemenceau, Sue-Ling Chang, Mirette Hanna, Francine Durocher, Caroline Diorio. DOI 10.1097/gme.0000000000002070

Sleep quality traits correlate with inflammatory markers in the breast tissue of women Cytokine, 2022. Sue-Ling Chang, Francine Durocher, Caroline Diorio. DOI 10.1016/j.cyto.2022.156028

Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers BMC Cancer, 2022. Emilie Wong Chong, France-Hélène Joncas, Nabil G. Seidah, Frédéric Calon, Caroline Diorio, Anne Gangloff. DOI 10.1186/s12885-022-10120-6

Knockdown of CKAP2 Inhibits Proliferation, Migration, and Aggregate Formation in Aggressive Breast Cancer Cancers, 2022. Alexsandro dos Santos, Geneviève Ouellete, Caroline Diorio, Sabine Elowe, Francine Durocher. DOI 10.3390/cancers14153759

Association between Alcohol Consumption and DNA Methylation in Blood: A Systematic Review of Observational Studies Epigenomics, 2022. Dzevka Dragic, Sue-Ling Chang, Kaoutar Ennour-Idrissi, Francine Durocher, Gianluca Severi, Caroline Diorio. DOI 10.2217/epi-2022-0055

Association between genome-wide epigenetic and genetic alterations in breast cancer tissue and response to HER2-targeted therapies in HER2-positive breast cancer patients: new findings and a systematic review Cancer Drug Resistance, 2022. Daniela Furrer, Dzevka Dragic, Sue-Ling Chang, Frédéric Fournier, Arnaud Droit, Simon Jacob, Caroline Diorio. DOI 10.20517/cdr.2022.63

Association of Breast Tumour Expression of Cannabinoid Receptors CBR1 and CBR2 with Prognostic Factors and Survival in Breast Cancer Patients Journal of Personalized Medicine, 2021. Jessica Morin-Buote, Kaoutar Ennour-Idrissi, Éric Poirier, Julie Lemieux, Daniela Furrer, Anna Burguin, Francine Durocher, Caroline Diorio. DOI 10.3390/jpm11090852

Identifying Clinicopathological Factors Associated with Oncotype DX® 21-Gene Recurrence Score: A Real-World Retrospective Cohort Study of Breast Cancer Patients in Quebec City, Canada Journal of Personalized Medicine, 2021. Simon Gagnet, Caroline Diorio, Louise Provencher, Cynthia Mbuya-Bienge, Julie Lapointe, Claudya Morin, Julie Lemieux, Hermann Nabi. DOI 10.3390/jpm11090858

Breast Cancer Treatments: Updates and New Challenges Journal of Personalized Medicine, 2021. Anna Burguin, Caroline Diorio, Francine Durocher. DOI 10.3390/jpm11080808

Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity Journal of Obesity, 2021. Sue-Ling Chang, André Tchernof, Francine Durocher, Caroline Diorio. DOI 10.1155/2021/3620147

TBC1D9: An Important Modulator of Tumorigenesis in Breast Cancer Cancers, 2021. Charu Kothari, Alisson Clemenceau, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Annick Michaud, René C.-Gaudreault, Caroline Diorio, Francine Durocher. DOI 10.3390/cancers13143557

Is Carboxypeptidase B1 a Prognostic Marker for Ductal Carcinoma In Situ? Cancers, 2021. Charu Kothari, Alisson Clemenceau, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Annick Michaud, Caroline Diorio, Francine Durocher. DOI 10.3390/cancers13071726

Psychosocial stressors at work and inflammatory biomarkers: PROspective Quebec Study on Work and Health Psychoneuroendocrinology, 2021. Duchaine, C.S., Brisson, C., Talbot, D., Gilbert-Ouimet, M., Trudel, X., Vézina, M., Milot, A., Diorio, C., Ndjaboué, R., Giguère, Y., Mâsse, B., Dionne, C.E., Maunsell, E., Laurin, D.. DOI 10.1016/j.psyneuen.2021.105400

Cumulative exposure to psychosocial stressors at work and global cognitive function: The PROspective Quebec Study on Work and Health Occupational and Environmental Medicine, 2021. Duchaine, C.S., Brisson, C., Talbot, D., Gilbert-Ouimet, M., Trudel, X., Vézina, M., Milot, A., Diorio, C., Ndjaboué, R., Giguère, Y., Mâsse, B., Dionne, C.E., Maunsell, E., Laurin, D.. DOI 10.1136/oemed-2021-107407

Associations between markers of mammary adipose tissue dysfunction and breast cancer prognostic factors International Journal of Obesity, 2021. Sofia Laforest, Kaoutar Ennour-Idrissi, Geneviève Ouellette, Marie-Frédérique Gauthier, Annick Michaud, Francine Durocher, André Tchernof, Caroline Diorio. DOI 10.1038/s41366-020-00676-3