Cristoforo Silvestri

• Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Affilié à l’Université Laval)
• Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (Reconnu FRQ - secteur santé)
• Centre Nutrition, santé et société
• Centre thématique de recherche en neurosciences

Financements des 2 dernières années

• Besma Boubertakh, Doctorat en médecine moléculaire
• Nayudu Nallabelli, Doctorat en médecine moléculaire

Encadrements des 5 dernières années

• Giada Giorgini, Doctorat en neurosciences
• Maëlle Colin, Maîtrise en biologie - avec mémoire
• Mehdi Zineddine Messaoudene, Maîtrise en microbiologie-immunologie - avec mémoire
• Pejman Abbasi Pashaki, Doctorat en médecine moléculaire

Travaux de recherche des 5 dernières années

Endocannabinoids and related lipids in host metabolism–gut microbiome signalling Nature Reviews Endocrinology, 2026. Cristoforo Silvestri, Vincenzo Di Marzo. DOI 10.1038/s41574-026-01289-y

Intestinal colonization of germ-free mice with indole-producing E. coli modulates the central and peripheral endocannabinoidome Journal of Lipid Research, 2026. Giada Giorgini, Hayatte-Dounia Mir, Camille Etienne, Élizabeth Dumais, Elise Maximin, Cristoforo Silvestri, Nicolas Flamand, Laurent Naudon, Sylvie Rabot, Vincenzo Di Marzo. DOI 10.1016/j.jlr.2026.101070

Circadian disruption alters hepatic calcium hemostasis, endocannabinoidome and mitochondria through N-docosahexaenoyl ethanolamide-GPR110 signaling 2026. Pejman A. Pashaki, Timothy Niepokny, Elizabeth Dumais, Eric M. Mintz, David Marsolais, Alain Veilleux, Nicolas Flamand, Vincenzo Di Marzo, Cristoforo Silvestri. DOI 10.64898/2026.06.10.731470

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses The FEBS Journal, 2026. Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri. DOI 10.1111/febs.70592

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia The FASEB Journal, 2026. Hayatte‐Dounia Mir, Giada Giorgini, Irene Santos‐García, Elizabeth Dumais, Carmen Rodríguez‐Cueto, Eva de Lago, Cristoforo Silvestri, Nicolas Flamand, Javier Fernández‐Ruiz, Vincenzo Di Marzo. DOI 10.1096/fj.202502312RR

Anti-obesity effects of Oleoylethanolamide: Modulation of mitochondrial bioenergetics, endocannabinoidome and gut microbiome Biomedicine & Pharmacotherapy, 2025. Fabiano Cimmino, Cristoforo Silvestri, Giovanna Trinchese, Lidia Petrella, Gina Cavaliere, Chiara Fogliano, Fabiana Piscitelli, Luigia Cristino, Bice Avallone, Sebastiano Banni, Jyoti Sihag, Vincenzo Di Marzo, Maria Pina Mollica. DOI 10.1016/j.biopha.2025.118201

Human Gut Microbes Produce EPA‐ and DHA‐Derived Oxylipins, but not N‐Acyl‐Ethanolamines, From Fish Oil The FASEB Journal, 2025. C. Roussel, J. Lessard‐Lord, N. Nallabelli, C. Muller, N. Flamand, C. Silvestri, V. Di Marzo. DOI 10.1096/fj.202500752RR

Mathematical modeling of fluid dynamics in in vitro gut fermentation systems: A new tool to improve the interpretation of microbial metabolism The FASEB Journal, 2024. Jacob Lessard‐Lord, Joseph Lupien‐Meilleur, Charlène Roussel, Benjamin Gosselin‐Cliche, Cristoforo Silvestri, Vincenzo Di Marzo, Denis Roy, Elsa Rousseau, Yves Desjardins. DOI 10.1096/fj.202301739RR

Effect of a Probiotic Beverage Enriched with Cricket Proteins on the Gut Microbiota: Composition of Gut and Correlation with Nutritional Parameters Foods, 2024. Chaima Dridi, Mathieu Millette, Stephane Salmieri, Blanca R. Aguilar Uscanga, Sebastien Lacroix, Tommaso Venneri, Elham Sarmast, Zahra Allahdad, Vincenzo Di Marzo, Cristoforo Silvestri, Monique Lacroix. DOI 10.3390/foods13020204

New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation Journal of Lipid Research, 2023. Besma Boubertakh, Olivier Courtemanche, David Marsolais, Vincenzo Di Marzo, Cristoforo Silvestri. DOI 10.1016/j.jlr.2023.100444

Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity Communications Biology, 2023. Nicola Forte, Charlène Roussel, Brenda Marfella, Anna Lauritano, Rosaria Villano, Elvira De Leonibus, Emanuela Salviati, Tina Khalilzadehsabet, Giada Giorgini, Cristoforo Silvestri, Fabiana Piscitelli, Maria Pina Mollica, Vincenzo Di Marzo, Luigia Cristino. DOI 10.1038/s42003-023-05295-y

A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese (ob/ob) and Diabetic (db/db) Mice: Links with Inflammation and Gut Microbiota Cells, 2023. Francesco Suriano, Claudia Manca, Nicolas Flamand, Matthias Van Hul, Nathalie M. Delzenne, Cristoforo Silvestri, Patrice D. Cani, Vincenzo Di Marzo. DOI 10.3390/cells12030411

Obesity: The Fat Tissue Disease Version of Cancer Cells, 2022. Besma Boubertakh, Cristoforo Silvestri, Vincenzo Di Marzo. DOI 10.3390/cells11121872

Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2022. Suriano, F., Manca, C., Flamand, N., Depommier, C., Van Hul, M., Delzenne, N.M., Silvestri, C., Cani, P.D., Di Marzo, V.. DOI 10.1016/j.bbalip.2021.159056

Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome Molecules, 2021. Mélissa Shen, Claudia Manca, Francesco Suriano, Nayudu Nallabelli, Florent Pechereau, Bénédicte Allam-Ndoul, Fabio Arturo Iannotti, Nicolas Flamand, Alain Veilleux, Patrice D. Cani, Cristoforo Silvestri, Vincenzo Di Marzo. DOI 10.3390/molecules27010001

Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis International Journal of Molecular Sciences, 2021. Armita Abolghasemi, Claudia Manca, Fabio A. Iannotti, Melissa Shen, Nadine Leblanc, Sébastien Lacroix, Cyril Martin, Nicolas Flamand, Vincenzo Di Marzo, Cristoforo Silvestri. DOI 10.3390/ijms222212361

Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity Biomedicines, 2021. Claudia Manca, Sébastien Lacroix, Francine Pérusse, Nicolas Flamand, Yvon Chagnon, Vicky Drapeau, Angelo Tremblay, Vincenzo Di Marzo, Cristoforo Silvestri. DOI 10.3390/biomedicines9091246

Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils Cells, 2021. Anne-Sophie Archambault, Francesco Tinto, Élizabeth Dumais, Volatiana Rakotoarivelo, Magdalena Kostrzewa, Pier-Luc Plante, Cyril Martin, Mélissa Simard, Cristoforo Silvestri, Roxane Pouliot, Michel Laviolette, Louis-Philippe Boulet, Rosa Maria Vitale, Alessia Ligresti, Vincenzo Di Marzo, Nicolas Flamand. DOI 10.3390/cells10092322

Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists Cells, 2021. Clara Depommier, Rosa Maria Vitale, Fabio Arturo Iannotti, Cristoforo Silvestri, Nicolas Flamand, Céline Druart, Amandine Everard, Rudy Pelicaen, Dominique Maiter, Jean-Paul Thissen, Audrey Loumaye, Michel P. Hermans, Nathalie M. Delzenne, Willem M. de Vos, Vincenzo Di Marzo, Patrice D. Cani. DOI 10.3390/cells10010185

Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure Prostaglandins Leukotrienes and Essential Fatty Acids, 2021. Bertrand, J.A., Woodward, D.F., Sherwood, J.M., Spenlehauer, A., Silvestri, C., Piscitelli, F., Marzo, V.D., Yamazaki, M., Sakimura, K., Inoue, Y., Watanabe, K., Overby, D.R.. DOI 10.1016/j.plefa.2020.102235

Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators Frontiers in Pharmacology, 2021. Ayoub, S.M., Piscitelli, F., Silvestri, C., Limebeer, C.L., Rock, E.M., Smoum, R., Farag, M., de Almeida, H., Sullivan, M.T., Lacroix, S., Boubertakh, B., Nallabelli, N., Lichtman, A.H., Leri, F., Mechoulam, R., Di Marzo, V., Parker, L.A.. DOI 10.3389/fphar.2021.706703