François Gros-Louis

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche en organogenèse expérimentale
• Centre thématique de recherche en neurosciences

Financements des 2 dernières années

• Alexandre Paquet, Doctorat en médecine moléculaire
• Alyssa Brodeur, Doctorat en sciences cliniques et biomédicales
• Isabella Bienjonetti, Doctorat en neurosciences

Encadrements des 5 dernières années

• Alexandre Paquet, Maîtrise en sciences cliniques et biomédicales - avec mémoire
• Alyssa Brodeur, Maîtrise en sciences cliniques et biomédicales - avec mémoire
• Vincent Clément, Doctorat en sciences cliniques et biomédicales
• Vincent Clément, Maîtrise en sciences cliniques et biomédicales - avec mémoire

Travaux de recherche des 5 dernières années

An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants Nature Communications, 2025. Nmezi, B., Rodriguez Bey, G., Oranburg, T.D., Dudnyk, K., Lardo, S.M., Herdman, N., Jacko, A., Rubio, S., Loeza-Alcocer, E., Kofler, J., Kim, D., Rankin, J., Kivuva, E., Gutowski, N., Schon, K., van den Ameele, J., Chinnery, P.F., Sousa, S.B., Palavra, F., Toro, C., Pinto e Vairo, F., Saute, J., Pan, L., Alturkustani, M., Hammond, R., Gros-Louis, F., Gold, M.S., Park, Y., Bernard, G., Raininko, R., Zhou, J., Hainer, S.J., Padiath, Q.S.. DOI 10.1038/s41467-025-56378-9

Self-Produced Brain-Like ECM From 3D-Cultured Dermal Fibroblasts Enhances Neuronal Growth and Survival Biotechnology Journal, 2025. Roy, V., Bienjonetti, I., Paquet, A., Gros-Louis, F.. DOI 10.1002/biot.202400594

Bioengineering Human Upper Respiratory Mucosa: A Systematic Review of the State of the Art of Cell Culture Techniques Bioengineering, 2024. Davaine Joel Ndongo Sonfack, Clémence Tanguay Boivin, Lydia Touzel Deschênes, Thibault Maurand, Célina Maguemoun, François Berthod, François Gros-Louis, Pierre-Olivier Champagne. DOI 10.3390/bioengineering11080826

LMNB1-duplication mediated nuclear architecture alteration and demyelination of cerebral white matter in a patient with ADLD Neuropathology and Applied Neurobiology, 2024. Roy, V., Bienjonetti, I., Brodeur, A., Dion-Albert, L., Touzel-Deschênes, L., Gould, P.V., Saikali, S., Laforce, R., Gros-Louis, F.. DOI 10.1111/nan.12947

Transcriptomic Analysis of Mineralized Adipose-Derived Stem Cell Tissues for Calcific Valve Disease Modelling International Journal of Molecular Sciences, 2024. Brodeur, A., Roy, V., Touzel-Deschênes, L., Bianco, S., Droit, A., Fradette, J., Ruel, J., Gros-Louis, F.. DOI 10.3390/ijms25042291

RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent Manner Cells, 2023. Roy, V., Brodeur, A., Touzel Deschênes, L., Dupré, N., Gros-Louis, F.. DOI 10.3390/cells12010078

Spherical rotary cell seeding system for production of small-caliber tissue-engineered blood vessels with complex geometry Scientific Reports, 2023. Brodeur, A., Winter, A., Roy, V., Touzel Deschênes, L., Gros-Louis, F., Ruel, J.. DOI 10.1038/s41598-023-29825-0

In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Stem Cells International, 2023. Louit, A., Beaudet, M.-J., Blais, M., Gros-Louis, F., Dupré, N., Berthod, F.. DOI 10.1155/2023/1496597

An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants Biorxiv, 2023. Nmezi, B., Bey, G.R., De Francesco Oranburg, T., Dudnyk, K., Lardo, S.M., Herdman, N., Jacko, A., Rubio, S., Alcocer, E.L., Kofler, J., Kim, D., Rankin, J., Kivuva, E., Gutowski, N., Schon, K., van den Ameele, J., Chinnery, P.F., Sousa, S.B., Palavra, F., Toro, C., Vairo, F.P.E., Saute, J., Pan, L., Alturkustani, M., Hammond, R., Gros-Louis, F., Gold, M., Park, Y., Bernard, G., Raininko, R., Zhou, J., Hainer, S.J., Padiath, Q.S.. DOI 10.1101/2023.08.03.551473

Heterozygous NF1 dermal fibroblasts modulate exosomal content to promote angiogenesis in a tissue-engineered skin model of neurofibromatosis type-1 Journal of Neurochemistry, 2023. Roy, V., Paquet, A., Touzel-Deschênes, L., Khuong, H.T., Dupré, N., Gros-Louis, F.. DOI 10.1111/jnc.15982

Autosomal and X-Linked Degenerative Ataxias: From Genetics to Promising Therapeutics Contemporary Clinical Neuroscience, 2023. Hadji, A., Louit, A., Roy, V., Blais, M., Berthod, F., Gros-Louis, F., Dupré, N.. DOI 10.1007/978-3-031-24345-5_5

Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations Stem Cell Research, 2022. Bchetnia, M., Martineau, L., Racine, V., Powell, J., McCuaig, C., Morin, C., Dupérée, A., Gros-Louis, F., Laprise, C.. DOI 10.1016/j.scr.2022.102726

Generation of two induced pluripotent stem cell lines (UQACi002-A and UQACi005-A) from two patients with KRT14 epidermolysis bullosa simplex mutations Stem Cell Research, 2022. Bchetnia, M., Martineau, L., Racine, V., Powell, J., McCuaig, C., Morin, C., Dupérée, A., Gros-Louis, F., Laprise, C.. DOI 10.1016/j.scr.2022.102750

Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function Stroke, 2022. Roy, V., Ross, J.P., Pépin, R., Cortez Ghio, S., Brodeur, A., Touzel Deschênes, L., Le-Bel, G., Phillips, D.E., Milot, G., Dion, P.A., Guérin, S., Germain, L., Berthod, F., Auger, F.A., Rouleau, G.A., Dupré, N., Gros-Louis, F.. DOI 10.1161/STROKEAHA.120.032691

Impact of Exosomes Released by Different Corneal Cell Types on the Wound Healing Properties of Human Corneal Epithelial Cells International Journal of Molecular Sciences, 2022. Desjardins, P., Berthiaume, R., Couture, C., Le-Bel, G., Roy, V., Gros-Louis, F., Moulin, V.J., Proulx, S., Chemtob, S., Germain, L., Guérin, S.L.. DOI 10.3390/ijms232012201

Persisting chemosensory impairments in 366 healthcare workers following COVID-19: an 11-month follow-up Chemical Senses, 2022. Bussiere, N., Mei, J., Levesque-Boissonneault, C., Blais, M., Carazo, S., Gros-Louis, F., Laforce, R., De Serres, G., Dupre, N., Frasnelli, J.. DOI 10.1093/chemse/bjac010

Tissue-engineered in vitro modeling of the impact of Schwann cells in amyotrophic lateral sclerosis Biotechnology and Bioengineering, 2022. Louit, A., Beaudet, M.-J., Gros-Louis, F., Berthod, F.. DOI 10.1002/bit.28083

Tridimensional cell culture of dermal fibroblasts promotes exosome-mediated secretion of extracellular matrix proteins Scientific Reports, 2022. Clément, V., Roy, V., Paré, B., Goulet, C.R., Deschênes, L.T., Berthod, F., Bolduc, S., Gros-Louis, F.. DOI 10.1038/s41598-022-23433-0

Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of over 700 Healthcare Workers Chemical Senses, 2021. Bussière, N., Mei, J., Lévesque-Boissonneault, C., Blais, M., Carazo, S., Gros-Louis, F., De Serres, G., Dupré, N., Frasnelli, J.. DOI 10.1093/chemse/bjab038

Persisting Chemosensory Impairments in 366 Healthcare Workers Following COVID-19: An 11-Month Follow-up Medrxiv, 2021. Bussiere, N., Mei, J., Levesque-Boissonneault, C., Blais, M., Carazo, S., Gros-Louis, F., Laforce, R., De Serres, G., Dupre, N., Frasnelli, J.. DOI 10.1101/2021.12.20.21268066

Biofabrication of a three dimensional human-based personalized neurofibroma model Biotechnology Journal, 2021. Roy, V., Lamontagne, R., Talagas, M., Touzel-Deschênes, L., Khuong, H.T., Saikali, S., Dupré, N., Gros-Louis, F.. DOI 10.1002/biot.202000250

The Biobanque québécoise de la COVID-19 (BQC19)-A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories Plos One, 2021. Tremblay, K., Rousseau, S., Zawati, M.H., Auld, D., Chasse, M., Coderre, D., Falcone, E.L., Gauthier, N., Grandvaux, N., Gros-Louis, F., Jabet, C., Joly, Y., Kaufmann, D.E., Laprise, C., Larochelle, C., Maltais, F., Mes-Masson, A.-M., Montpetit, A., Piche, A., Brent Richards, J., Tse, S.M., Turgeon, A.F., Turecki, G., Vinh, D.C., Wang, H.T., Mooser, V.. DOI 10.1371/journal.pone.0245031