Jacques Côté

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche sur le cancer
• Centre de recherche sur les protéines PROTEO-ULaval

Financements des 2 dernières années

• Diksha Singh, Doctorat en biologie cellulaire et moléculaire
• Emile Clerf, Doctorat en biologie cellulaire et moléculaire
• Golareh Asgaritarghi, Doctorat en biologie cellulaire et moléculaire
• Himanshu Gupta, Stage postdoctoral en biologie cellulaire et moléculaire
• Juan Carlos Yustis Rubio, Maîtrise en biologie cellulaire et moléculaire - avec mémoire
• Maëlys Le Goff, Maîtrise en biologie cellulaire et moléculaire - avec mémoire
• Maëlys Le Goff, Doctorat en biologie cellulaire et moléculaire
• Maryam Motiolah, Doctorat en biologie cellulaire et moléculaire
• Mathieu Dugas, Maîtrise en biologie cellulaire et moléculaire - avec mémoire
• Vasilisa Pozharskaia, Stage postdoctoral en biologie cellulaire et moléculaire

Encadrements des 5 dernières années

• Amel Mameri, Doctorat en biologie cellulaire et moléculaire
• Amel Mameri, Maîtrise en biologie cellulaire et moléculaire - avec mémoire
• Deepthi Sudarshan, Doctorat en biologie cellulaire et moléculaire
• Jonathan Humbert, Doctorat en biologie cellulaire et moléculaire
• Ke Xu, Doctorat en biologie cellulaire et moléculaire
• Tiina Viita, Stage postdoctoral en médecine

Travaux de recherche des 5 dernières années

An intricate functional relationship between NuA4 and Sfp1 regulates ribosome biogenesis in response to nutrient availability Journal of Biological Chemistry, 2026. Ke Xu, Stéphanie Bianco, Charles Joly Beauparlant, Valérie Côté, Lara Herrmann, Arnaud Droit, Michael Downey, Amine Nourani, Jacques Côté. DOI 10.1016/j.jbc.2026.113107

Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction Journal of Biological Chemistry, 2025. Soumi Biswas, Ji-Eun Lee, Guojia Xie, Louis Masclef, Zhizhong Ren, Jacques Côté, El Bachir Affar, Kai Ge, Tatiana G. Kutateladze. DOI 10.1016/j.jbc.2025.108333

Concomitant acetylation and loading of H2A.Z by NuA4/TIP60 regulate target gene transcription Biorxiv, 2025. Mameri, A., Lachance, C., Cattoglio, C., Bianco, S., Humbert, J., Joly-Beauparlant, C., Texeraud, E., Banerjea, A., Lashgari, A., Lambert, J.-P., Hussein, S.M.I., Droit, A., Côté, J.. DOI 10.1101/2025.09.22.677705

Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation Nature Communications, 2025. Vann, K.R., Sharma, R., Hsu, C.-C., Devoucoux, M., Tencer, A.H., Zeng, L., Lin, K., Zhu, L., Li, Q., Lachance, C., Ospina, R.R., Tong, Q., Cheung, K.L., Yang, S., Biswas, S., Xuan, H., Gatchalian, J., Alamillo, L., Wang, J., Jang, S.M., Klein, B.J., Lu, Y., Ernst, P., Strahl, B.D., Rothbart, S.B., Walsh, M.J., Cleary, M.L., Côté, J., Shi, X., Zhou, M.-M., Kutateladze, T.G.. DOI 10.1038/s41467-025-57556-5

A needed nomenclature for nucleosomes Molecular Cell, 2025. Keogh, M.-C., Almouzni, G., Andrews, A.J., Armache, K.-J., Arrowsmith, C.H., Baek, S.H., Bedford, M.T., Bernstein, E., Côté, J., David, Y., Denu, J.M., Fierz, B., Garcia, B.A., Glass, K.C., Gozani, O., Helin, K., Henikoff, S., Jensen, O.N., Josefowicz, S.Z., Kelleher, N.L., Kutateladze, T.G., Lindner, H.H., Lu, C., Luger, K., Mallick, P., Musselman, C.A., Muir, T.W., Paša-Tolić, L., Schneider, R., Shi, X., Shi, Y., Sidoli, S., Smith, L.M., Tyler, J.K., Wolberger, C., Workman, J.L., Strahl, B.D., Young, N.L.. DOI 10.1016/j.molcel.2025.08.029

A multivalent engagement of ENL with MOZ Nature Structural and Molecular Biology, 2025. Becht, D.C., Selvam, K., Lachance, C., Côté, V., Li, K., Nguyen, M.C., Pareek, A., Shi, X., Wen, H., Blanco, M.A., Côté, J., Kutateladze, T.G.. DOI 10.1038/s41594-024-01455-8

Anchor-Away: Efficient, Conditional Depletion of Nuclear Proteins in Saccharomyces cerevisiae Methods in Molecular Biology, 2025. Xu, K., Côté, V., Côté, J.. DOI 10.1007/978-1-0716-4486-7_15

Functional interaction between transcription factor Sfp1 and the NuA4 complex in response to nutrient availability 2024. Ke Xu, Stéphanie Bianco, Charles Joly Beauparlant, Valérie Côté, Lara Herrmann, Arnaud Droit, Michael Downey, Amine Nourani, Jacques Côté. DOI 10.1101/2024.10.28.620578

Histone H2A variants play a key role at DNA double-strand breaks during repair pathway choice Frontiers in Epigenetics and Epigenomics, 2024. Emile Clerf, Maxime Galloy, Amélie Fradet-Turcotte, Jacques Côté. DOI 10.3389/freae.2024.1445765

Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex Science, 2024. Yang, Z., Mameri, A., Cattoglio, C., Lachance, C., Ariza, A.J.F., Luo, J., Humbert, J., Sudarshan, D., Banerjea, A., Galloy, M., Fradet-Turcotte, A., Lambert, J.-P., Ranish, J.A., Côté, J., Nogales, E.. DOI 10.1126/science.adl5816

HBO1, a MYSTerious KAT and its links to cancer Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 2024. Yokoyama, A., Niida, H., Kutateladze, T.G., Côté, J.. DOI 10.1016/j.bbagrm.2024.195045

The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling EMBO Reports, 2024. Collin, V., Biquand, É., Tremblay, V., Lavoie, É.G., Blondeau, A., Gravel, A., Galloy, M., Lashgari, A., Dessapt, J., Côté, J., Flamand, L., Fradet-Turcotte, A.. DOI 10.1038/s44319-023-00035-z

ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers Nature Communications, 2024. Zhang, Y., Xie, G., Lee, J.-E., Zandian, M., Sudarshan, D., Estavoyer, B., Benz, C., Viita, T., Asgaritarghi, G., Lachance, C., Messmer, C., Simonetti, L., Sinha, V.K., Lambert, J.-P., Chen, Y.-W., Wang, S.-P., Ivarsson, Y., Affar, E.B., Côté, J., Ge, K., Kutateladze, T.G.. DOI 10.1038/s41467-024-49391-x

Guiding the HBO1 complex function through the JADE subunit Nature Structural and Molecular Biology, 2024. Gaurav, N., Kanai, A., Lachance, C., Cox, K.L., Liu, J., Grzybowski, A.T., Saksouk, N., Klein, B.J., Komata, Y., Asada, S., Ruthenburg, A.J., Poirier, M.G., Côté, J., Yokoyama, A., Kutateladze, T.G.. DOI 10.1038/s41594-024-01245-2

The Functional Relationship Between RNA Splicing and the Chromatin Landscape Journal of Molecular Biology, 2024. Yustis, J.-C., Devoucoux, M., Côté, J.. DOI 10.1016/j.jmb.2024.168614

JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex. Frontiers in cell and developmental biology, 2023. Mameri A, Côté J. DOI 10.3389/fcell.2023.1134268

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain. Nature communications, 2023. Becht DC, Klein BJ, Kanai A, Jang SM, Cox KL, Zhou BR, Phanor SK, Zhang Y, Chen RW, Ebmeier CC, Lachance C, Galloy M, Fradet-Turcotte A, Bulyk ML, Bai Y, Poirier MG, Côté J, Yokoyama A, Kutateladze TG. DOI 10.1038/s41467-023-36368-5

The MOZ-BRPF1 acetyltransferase complex in epigenetic crosstalk linked to gene regulation, development, and human diseases. Frontiers in cell and developmental biology, 2023. Viita T, Côté J. DOI 10.3389/fcell.2022.1115903

Characterization of multiple interactions between the envelope E protein of SARS-CoV-2 and human BRD4 STAR Protocols, 2022. Jacques Cote, Mohamad Zandian, Suk Min Jang, Catherine Lachance, Arpan Acharya, Siddappa N. Byrareddy, Jacques Côté, Tatiana G. Kutateladze. DOI 10.1016/j.xpro.2022.101853

A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in <i>Saccharomyces cerevisiae</i> and humans Genetics, 2022. Phoebe Y T Lu, Alyssa C Kirlin, Maria J Aristizabal, Hilary T Brewis, Nancy Lévesque, Dheva T Setiaputra, Nikita Avvakumov, Joris J Benschop, Marian Groot Koerkamp, Frank C P Holstege, Nevan J Krogan, Calvin K Yip, Jacques Côté, Michael S Kobor. DOI 10.1093/genetics/iyac136

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes Cell Reports, 2022. Jacques Cote. DOI 10.1016/j.celrep.2022.110947

Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci Genes & Development, 2022. Jacques Cote. DOI 10.1101/gad.348982.121

Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection Structure, 2022. Jacques Cote. DOI 10.1016/j.str.2022.05.020

MRG proteins are shared by multiple protein complexes with distinct functions. Molecular & cellular proteomics : MCP, 2022. DOI 10.1016/j.mcpro.2022.100253

New insights into the DNA repair pathway choice with NuA4/TIP60. DNA repair, 2022. DOI 10.1016/j.dnarep.2022.103315

Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states. Genes & development, 2022. DOI 10.1101/gad.349039.121

NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis Nature Communications, 2022. Jacques Cote. DOI 10.1038/s41467-021-27882-5

DNA damage-induced phosphorylation of histone H2A at serine 15 is linked to DNA end resection. Molecular and cellular biology, 2021. DOI 10.1128/mcb.00056-21

Approaches to Study Native Chromatin-Modifying Complex Activities and Functions Frontiers in Cell and Developmental Biology, 2021. DOI 10.3389/fcell.2021.729338

Structural and biophysical characterization of the nucleosome-binding PZP domain. STAR protocols, 2021. DOI 10.1016/j.xpro.2021.100479

DNA damage-induced phosphorylation of histone H2A at serine 15 is linked to DNA end resection Biorxiv, 2021. Ahmad, S., Côté, V., Côté, J.. DOI 10.1101/2021.02.08.430376

Antagonistic relationship of NuA4 with the non-homologous end-joining machinery at DNA damage sites Plos Genetics, 2021. Ahmad, S., Côté, V., Cheng, X., Bourriquen, G., Sapountzi, V., Altaf, M., Côté, J.. DOI 10.1371/journal.pgen.1009816

NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination Biorxiv, 2021. Cheng, X., Côte, J., Côté, V.. DOI 10.1101/2021.03.04.433861