Jacques J. Tremblay

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche en reproduction, développement et santé intergénérationnelle

Financements des 2 dernières années

• Kenley Joule Pierre, Doctorat en médecine moléculaire
• Léa Lafranchise, Maîtrise en médecine moléculaire - avec mémoire
• Léa Lafranchise, Doctorat en médecine moléculaire
• Ryme Barkatou, Maîtrise en médecine moléculaire - avec mémoire

Encadrements des 5 dernières années

• Karine De Mattos, Doctorat en médecine moléculaire
• Kenley Joule Pierre, Maîtrise en médecine moléculaire - avec mémoire
• Laurie Boudreau, Maîtrise en médecine moléculaire - avec mémoire
• Shirley Ferrier Tarin, Maîtrise en médecine moléculaire - avec mémoire
• Zoheir Benaoumer Demmouche, Doctorat en médecine moléculaire

Travaux de recherche des 5 dernières années

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells Andrology, 2026. Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay. DOI 10.1111/andr.70051

Genetic ablation of the adult Leydig cell lineage reveals stem Leydig cells and a peritubular regenerative niche in mice Endocrinology, 2026. Laurie Boudreau, Nicholas M Robert, Jacques J Tremblay. DOI 10.1210/endocr/bqag113

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells Andrology, 2025. Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay.

[Commentary/Feature on our work] Insl3-iCre Mouse Line: A Novel Effective Tool for Targeting Leydig Cells to Study Their Development and Function. Endocrinology, 2025. Papadopoulos V. DOI 10.1210/endocr/bqaf048

A New Leydig Cell–Exclusive Cre Line Allows Lineage Tracing of Fetal and Adult Leydig Cell Populations in the Mouse Endocrinology, 2025. Nicholas M Robert, Shirley Ferrier-Tarin, Jacques J Tremblay. DOI 10.1210/endocr/bqaf012

Transcription Factors in Leydig Cells 2025. Karine de Mattos, Jacques J. Tremblay. DOI 10.1007/978-3-031-96376-6_9

A STAR for the ages: a 30-year historical perspective of the role of transcription factors in the regulation of steroidogenic acute regulatory gene expression Journal of Endocrinology, 2024. Robert S Viger, Marie France Bouchard, Jacques J Tremblay. DOI 10.1530/JOE-24-0087

Ethylene dimethanesulfonate effects on gene promoter activities related to the endocrine function of immortalized Leydig cell lines R2C and MA-10 Current Research in Toxicology, 2024. de Barros, J.W.F., Joule Pierre, K., Kempinas, W.D.G., Tremblay, J.J.. DOI 10.1016/j.crtox.2023.100147

ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells Endocrinology United States, 2023. De Mattos, K., Dumas, F.-O., Campolina-Silva, G.H., Belleanne, C., Viger, R.S., Tremblay, J.J.. DOI 10.1210/endocr/bqad120

Hormones and Signaling Pathways Involved in the Stimulation of Leydig Cell Steroidogenesis Endocrines, 2023. de Mattos, K., Pierre, K.J., Tremblay, J.J.. DOI 10.3390/endocrines4030041

The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells. Reproduction (Cambridge, England), 2022. Di-Luoffo M, Pierre KJ, Robert NM, Girard MJ, Tremblay JJ. DOI 10.1530/rep-22-0109

Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression. Frontiers in endocrinology, 2022. Viger RS, de Mattos K, Jacques J. Tremblay. DOI 10.3389/fendo.2022.902198

Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function. Frontiers in endocrinology, 2022. de Mattos K, Viger RS, Jacques J. Tremblay. DOI 10.3389/fendo.2022.881309

Mechanism of Action of an Environmentally Relevant Organochlorine Mixture in Repressing Steroid Hormone Biosynthesis in Leydig Cells† International Journal of Molecular Sciences, 2022. Enangue Njembele, A.N., Demmouche, Z.B., Bailey, J.L., Tremblay, J.J.. DOI 10.3390/ijms23073997

Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti-Müllerian hormone receptor type 2 transcription in mouse MA-10 Leydig cells Andrology, 2022. Mehanovic, S., Pierre, K.J., Viger, R.S., Tremblay, J.J.. DOI 10.1111/andr.13266

A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis International Journal of Molecular Sciences, 2022. Bouchard, M.F., Picard, J., Tremblay, J.J., Viger, R.S.. DOI 10.3390/ijms231912009

Dynamic Expression of the Homeobox Factor PBX1 during Mouse Testis Development † Endocrines, 2022. Moisan, V., Brousseau, C., Tremblay, J.J.. DOI 10.3390/endocrines3010002

Growth Hormone-induced STAT5B Regulates Star Gene Expression Through a Cooperation With cJUN in Mouse MA-10 Leydig Cells Endocrinology United States, 2022. Hébert-Mercier, P.-O., Bergeron, F., Robert, N.M., Mehanovic, S., Pierre, K.J., Mendoza-Villarroel, R.E., de Mattos, K., Brousseau, C., Tremblay, J.J.. DOI 10.1210/endocr/bqab267

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells † International Journal of Molecular Sciences, 2022. Pierre, K.J., Tremblay, J.J.. DOI 10.3390/ijms232113153

The Urokinase-Type Plasminogen Activator Contributes to cAMP-Induced Steroidogenesis in MA-10 Leydig Cells Endocrines, 2022. Demmouche, Z.B., Tremblay, J.J.. DOI 10.3390/endocrines3030037

Comprehensive and Quantitative Analysis of the Changes in Proteomic and Phosphoproteomic Profiles during Stimulation and Repression of Steroidogenesis in MA-10 Leydig Cells † International Journal of Molecular Sciences, 2022. Demmouche, Z.B., Tremblay, J.J.. DOI 10.3390/ijms232112846

A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells International Journal of Molecular Sciences, 2022. Giner, X.C., Pierre, K.J., Robert, N.M., Tremblay, J.J.. DOI 10.3390/ijms232315060

Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†. Biology of reproduction, 2021. Mehanovic S, Mendoza-Villarroel RE, de Mattos K, Talbot P, Viger RS, Jacques J. Tremblay. DOI 10.1093/biolre/ioab131

Mechanisms of mehp inhibitory action and analysis of potential replacement plasticizers on leydig cell steroidogenesis International Journal of Molecular Sciences, 2021. Enangue Njembele, A.N., Tremblay, J.J.. DOI 10.3390/ijms222111456