Marie-Claude Vohl

• Centre Nutrition, santé et société
• Institut sur la nutrition et les aliments fonctionnels

Financements des 2 dernières années

• Elhadji Al Badara Ningue, Maîtrise en nutrition - avec mémoire
• Loubna Amzil, Doctorat en nutrition
• Valentin Barbe, Doctorat en nutrition
• William Gagnon, Doctorat en nutrition

Encadrements des 5 dernières années

• Ellie Gauthier, Maîtrise en nutrition - avec mémoire
• Josiane Morin-Bernier, Maîtrise en nutrition - avec mémoire
• Justine Keathley, Stage postdoctoral en agriculture
• Maximilien Christophe Franck, Doctorat en nutrition
• Rodrigo San Cristobal Blanco, Stage postdoctoral en nutrition
• Valentin Barbe, Maîtrise en nutrition - avec mémoire

Travaux de recherche des 5 dernières années

Eating Behaviors, Dietary Intakes, and Other Lifestyle Behaviors as Mediators of Genetic Susceptibility to Obesity: A Systematic Review Obesity Reviews, 2026. Benoît Boulanger, Laurence Pelletier, Angelo Tremblay, Marie‐Claude Vohl, Vicky Drapeau, Louis Pérusse. DOI 10.1111/obr.70239

Knowledge and Interest in Nutritional Genomics Among Clinical Dietitians in Kuwait: A Cross-Sectional Study Lifestyle Genomics, 2026. Esra Shishtar, Peter Eck, Marie-Claude Vohl, Ahmad Alsaber, Mohammad M H Abdullah, Fatemah Osama Al-muaili. DOI 10.1159/lfg/adlag003

Genome-wide association meta-analysis of eating behavior traits revealed one susceptibility locus for emotional eating Molecular Psychiatry, 2026. Manon Muntaner, Katrin Horn, Blandine de Lauzon-Guillain, Muriel Tafflet, Teemu Palviainen, Kirsi H. Pietiläinen, Guiomar Masip, Braxton D. Mitchell, Christian Couture, Marie-Claude Vohl, Janne Pott, Philippe Amouyel, Monique Romon, Louis Perusse, Nanette Steinle, Jaakko Kaprio, Barbara Heude, Anke Tönjes, Peter Kovacs, Markus Scholz, Aline Meirhaeghe. DOI 10.1038/s41380-026-03889-6

An integrated proteogenomic investigation of the human liver uncovers molecular drivers of steatotic liver disease 2026. Émilie Gobeil, Jérôme Bourgault, Malie Enault, Valérie Côté, Patricia L. Mitchell, Louis-Jacques Ruel, Arnaud S. Girard, Marie-Claude Vohl, Benoit J. Arsenault. DOI 10.64898/2026.06.04.26354903

Agnostic polygenic prediction of weight loss after bariatric surgery JCI Insight, 2026. Bastien Vallée Marcotte, Juan de Toro-Martín, André Tchernof, Louis Pérusse, Simon Marceau, Marie-Claude Vohl. DOI 10.1172/jci.insight.198133

Exploring mental health outcomes among genetic carriers and non-carriers of phenylketonuria (PKU) MOLECULAR GENETICS AND METABOLISM, 2026. DOI 10.1016/J.YMGME.2026.109784

PKU carriers exhibit altered mood and cognition in response to Lphenylalanine compared to non-carriers: The Phe for Me trial MOLECULAR GENETICS AND METABOLISM, 2026. DOI 10.1016/J.YMGME.2026.109787

Study protocol and pilot study results for a clinical intervention trial of PKU carriers and non-carriers: the Phe for Me trial ORPHANET JOURNAL OF RARE DISEASES, 2026. DOI 10.1186/S13023-025-04131-2

Functional gut microbiome signatures underlying interindividual variability in metabolic responses to red raspberry consumption SCIENTIFIC REPORTS, 2026. DOI 10.1038/S41598-026-45955-7

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2026. DOI 10.1210/CLINEM/DGAG043

Impact of <i>AKR1C2</i> and <i>AKR1C3</i> single-nucleotide polymorphism rs28571848 in adipose tissues of individuals with severe obesity AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2026. DOI 10.1152/AJPENDO.00512.2024

Machine learning-driven discovery of bioactive peptides from duckweed (Lemnaceae) protein hydrolysates: Identification and experimental validation of 20 novel antihypertensive, antidiabetic, and/or antioxidant peptides FOOD CHEMISTRY, 2025. DOI 10.1016/J.FOODCHEM.2025.144029

Exploring novel antifungal peptides from peptic hydrolysis of chicken cruor protein via regression-based machine learning approach FOOD CHEMISTRY, 2025. DOI 10.1016/J.FOODCHEM.2024.142606

Impact of AKR1C2 and AKR1C3 single nucleotide polymorphism rs28571848 in adipose tissues of individuals with severe obesity medRxiv, 2025. DOI 10.1101/2025.10.10.25337731

Pharmaco-nutraceutical improvement of the response to obeticholic acid with omega-3 polyunsaturated fatty acids BIOCHEMICAL JOURNAL, 2025. DOI 10.1042/BCJ20253113

RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: a drug-target Mendelian randomization study CARDIOVASCULAR RESEARCH, 2025. DOI 10.1093/CVR/CVAF078

Polygenic prediction of body mass index and obesity through the life course and across ancestries NATURE MEDICINE, 2025. DOI 10.1038/S41591-025-03827-Z

Fecal deoxycholic acid associates with diet, intestinal microbes, and total bilirubin in primary sclerosing cholangitis JHEP Reports, 2024. Connie Chan, Mateus Lemos, Peter Finnegan, William Gagnon, Richard Dean, Maryam Yazdanafar, Joseph Zepeda, Marie-Claude Vohl, Michael Trauner, Joshua R. Korzenik, Olivier Barbier, Maria L. Marco, Christopher L. Bowlus. DOI 10.1016/j.jhepr.2024.101188

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets EUROPEAN HEART JOURNAL OPEN, 2024. DOI 10.1093/EHJOPEN/OEAE043

Revisiting multi-omics-based predictors of the plasma triglyceride response to an omega-3 fatty acid supplementation(vol 11 , 1327863 , 2024) FRONTIERS IN NUTRITION, 2024. DOI 10.3389/FNUT.2024.1388485

Substituting Refined fi ned Sugars With Maple Syrup Decreases Key Cardiometabolic Risk Factors in Individuals With Mild Metabolic Alterations: A Randomized, Double-Blind, Controlled Crossover Trial JOURNAL OF NUTRITION, 2024. DOI 10.1016/J.TJNUT.2024.08.014

Metabolic-associated fatty liver disease is characterized by a post-oral glucose load hyperinsulinemia in individuals with mild metabolic alterations AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2024. DOI 10.1152/AJPENDO.00294.2023

RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: A drug-target Mendelian randomization study CIRCULATION, 2024. DOI 10.1161/CIRC.150.SUPPL_1.4141244

Upcycling calf cruor slaughterhouse by-product by peptic hydrolysis and identification of three novel antifungal peptides following a regression based-machine learning approach FOOD RESEARCH INTERNATIONAL, 2024. DOI 10.1016/J.FOODRES.2024.115045

Translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients-it takes a village APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2024. DOI 10.1139/APNM-2024-0111

Camu-camu decreases hepatic steatosis and liver injury markers in overweight, hypertriglyceridemic individuals: A randomized crossover trial CELL REPORTS MEDICINE, 2024. DOI 10.1016/J.XCRM.2024.101682

Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic risk EUROPEAN HEART JOURNAL, 2024. DOI 10.1093/EURHEARTJ/EHAD845

TOTUM-63 (T63), a Novel Plant-Based Polyphenol-Rich Substance, Improves Glucose Homeostasis and Modulates Gut Microbiota Diversity among Adults at Increased Cardiometabolic Risk DIABETES, 2024. DOI 10.2337/DB24-725-P

Revisiting multi-omics-based predictors of the plasma triglyceride response to an omega-3 fatty acid supplementation FRONTIERS IN NUTRITION, 2024. DOI 10.3389/FNUT.2024.1327863

Informing Evidence-based Practice in Nutritional Genomics: An Educational Needs Assessment of Nutrition Care Providers in Canada CANADIAN JOURNAL OF DIETETIC PRACTICE AND RESEARCH, 2024. DOI 10.3148/CJDPR-2024-010

A discriminant analysis of plasma metabolomics for the assessment of metabolic responsiveness to red raspberry consumption FRONTIERS IN NUTRITION, 2023. DOI 10.3389/FNUT.2023.1104685

Post-OGTT Low Blood Glucose in Individuals with Metabolic Syndrome, Metabolic Phenotypes, and Metabolic-Associated Fatty Liver Disease DIABETES, 2023. DOI 10.2337/DB23-1586-P

Post-Oral Glucose Load Hyperinsulinemia in Individuals with Metabolic Syndrome and Metabolic-Associated Fatty Liver Disease-First Steps toward the Development of Type 2 Diabetes? DIABETES, 2023. DOI 10.2337/DB23-1590-P

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets medRxiv, 2023. DOI 10.1101/2023.12.05.23299567

Precision Nutrition for Cardiovascular Diseases Prevention LIFESTYLE GENOMICS, 2023. DOI 10.1159/000529054

Heuristic approach uncovering biological significance of gene-lifestyle interactions in cardiometabolic traits. LIFESTYLE GENOMICS, 2023. DOI 10.1159/000531181

Update of a Genetic Risk Score Predictive of the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation in the FAS Study NUTRIENTS, 2023. DOI 10.3390/NU15051156

Impact of maternal cardiometabolic status after bariatric surgery on the association between telomere length and adiposity in offspring SCIENTIFIC REPORTS, 2023. DOI 10.1038/S41598-023-47813-2

Associations of fecal bile acids, diet, and intestinal microbes with markers of disease progression in primary sclerosing cholangitis disease JOURNAL OF HEPATOLOGY, 2023.

Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry Nutrients, 2022. William Gagnon, Véronique Garneau, Jocelyn Trottier, Mélanie Verreault, Charles Couillard, Denis Roy, André Marette, Jean-Philippe Drouin-Chartier, Marie-Claude Vohl, Olivier Barbier. DOI 10.3390/nu14183857

Raspberry consumption: identification of distinct immune-metabolic response profiles by whole blood transcriptome profiling (vol 101C, 108946, 2022) JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2022. DOI 10.1016/J.JNUTBIO.2022.109035

Guiding Global Best Practice in Personalized Nutrition Based on Genetics: The Development of a Nutrigenomics Care Map JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, 2022. DOI 10.1016/J.JAND.2021.02.008

Clinical Practice Guidelines Using GRADE and AGREE II for the Impact of Genetic Variants on Plasma Lipid/Lipoprotein/Apolipoprotein Responsiveness to Omega-3 Fatty Acids FRONTIERS IN NUTRITION, 2022. DOI 10.3389/FNUT.2021.768474

Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases COMMUNICATIONS MEDICINE, 2022. DOI 10.1038/S43856-022-00196-3

Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers GENOME MEDICINE, 2022. DOI 10.1186/S13073-022-01077-Z

Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study Preprints, 2022. DOI 10.20944/PREPRINTS202208.0202.V1

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity medRxiv, 2022. DOI 10.1101/2022.02.07.22270618

Raspberry consumption: identification of distinct immune-metabolic response profiles by whole blood transcriptome profiling JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2022. DOI 10.1016/J.JNUTBIO.2022.108946

Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation CURRENT NUTRITION REPORTS, 2022. DOI 10.1007/S13668-022-00430-3

Gut Microbial Signatures of Distinct Trimethylamine N-Oxide Response to Raspberry Consumption NUTRIENTS, 2022. DOI 10.3390/NU14081656

Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease METABOLITES, 2022. DOI 10.3390/METABO12050440

Eco-Evolutionary Dynamics of the Human-Gut Microbiota Symbiosis in a Changing Nutritional Environment EVOLUTIONARY BIOLOGY, 2022. DOI 10.1007/S11692-022-09569-X

Changes in systolic blood pressure, postprandial glucose, and gut microbial composition following mango consumption in individuals with overweight and obesity APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2022. DOI 10.1139/APNM-2021-0637

Nutrigenetics, omega-3 and plasma lipids/lipoproteins/apolipoproteins with evidence evaluation using the GRADE approach: a systematic review BMJ OPEN, 2022. DOI 10.1136/BMJOPEN-2021-054417

Molecular remodeling of adipose tissue is associated with metabolic recovery after weight loss surgery JOURNAL OF TRANSLATIONAL MEDICINE, 2022. DOI 10.1186/S12967-022-03485-6

Understanding Gene-Lifestyle Interaction in Obesity: The Role of Mediation versus Moderation LIFESTYLE GENOMICS, 2022. DOI 10.1159/000523813

Super-enhancer signature reveals key mechanisms associated with resistance to non-alcoholicsteatohepatitis in humans with obesity bioRxiv, 2022. DOI 10.1101/2021.08.20.457162

Are Machine Learning Algorithms More Accurate in Predicting Vegetable and Fruit Consumption Than Traditional Statistical Models? An Exploratory Analysis FRONTIERS IN NUTRITION, 2022. DOI 10.3389/FNUT.2022.740898

Gene expression signatures and cardiometabolic outcomes following 8-week mango consumption in individuals with overweight/obesity FRONTIERS IN NUTRITION, 2022. DOI 10.3389/FNUT.2022.918844

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity JCI INSIGHT, 2022. DOI 10.1172/JCI.INSIGHT.159204

Towards a Standardized Definition of Medical Nutrition Therapy and Regulatory Reform in Canada CANADIAN JOURNAL OF DIETETIC PRACTICE AND RESEARCH, 2022. DOI 10.3148/CJDPR-2021-033

Salmon peptides limit obesity‐associated metabolic disorders by modulating a gut‐liver axis in vitamin D‐deficient mice Obesity, 2021. Marion Valle, Patricia L. Mitchell, Geneviève Pilon, Thibault Varin, Loïc Hénault, Jonathan Rolin, Roger McLeod, Tom Gill, Denis Richard, Marie‐Claude Vohl, Hélène Jacques, Claudia Gagnon, Laurent Bazinet, André Marette.

AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants Molecular and Cellular Endocrinology, 2021. Giada Ostinelli, Jinchu Vijay, Marie-Claude Vohl, Elin Grundberg, Andre Tchernof.

Identification of Phenotypic Lipidomic Signatures in Response to Long Chain n‐3 Polyunsaturated Fatty Acid Supplementation in Humans Journal of the American Heart Association, 2021. Matthew Picklo, Bastien Vallée Marcotte, Michael Bukowski, Juan de Toro‐Martín, Bret M. Rust, Frédéric Guénard, Marie‐Claude Vohl.

Identification of Phenotypic Lipidomic Signatures in Response to Long Chain n-3 Polyunsaturated Fatty Acid Supplementation in Humans JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2021. DOI 10.1161/JAHA.120.018126

Associations Between Nutrition Knowledge and Overall Diet Quality: The Moderating Role of Sociodemographic Characteristics-Results From the PREDISE Study AMERICAN JOURNAL OF HEALTH PROMOTION, 2021. DOI 10.1177/0890117120928877JOURNALS.SAGEPUB.COM/HOME/AHP

<i>AKR1C2</i> and <i>AKR1C3</i> expression in adipose tissue: Association with body fat distribution and regulatory variants MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2021. DOI 10.1016/J.MCE.2021.111220

OMEGA-3 POLYUNSATURATED FATTY ACIDS IMPROVE THE RESPONSE TO OBETICHOLIC ACID IN VITRO: A PHARMACO-NUTRACEUTICAL STUDY HEPATOLOGY, 2021.

Comment on "Guiding Global Best Practice in Personalized Nutrition Based on Genetics: The Development of a Nutrigenomics Care Map" Response JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, 2021. DOI 10.1016/J.JAND.2021.04.017

A multivariable Mendelian randomization analysis disentangling the causal relations between abdominal obesity, non-alcoholic fatty liver disease and cardiometabolic diseases medRxiv, 2021. DOI 10.1101/2021.09.28.21264201

An 8-week freeze-dried blueberry supplement impacts immune-related pathways: a randomized, double-blind placebo-controlled trial GENES AND NUTRITION, 2021. DOI 10.1186/S12263-021-00688-2

Cholecalciferol Supplementation Does Not Prevent the Development of Metabolic Syndrome or Enhance the Beneficial Effects of Omega-3 Fatty Acids in Obese Mice JOURNAL OF NUTRITION, 2021. DOI 10.1093/JN/NXAB002

Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease CELL REPORTS MEDICINE, 2021. DOI 10.1016/J.XCRM.2021.100437

Mendelian randomization analysis identifies blood tyrosine levels as a biomarker of non-alcoholic fatty liver disease medRxiv, 2021. DOI 10.1101/2021.11.26.21266879

Associations of Intake of Free and Naturally Occurring Sugars from Solid Foods and Drinks with Cardiometabolic Risk Factors in a Quebec Adult Population: The PREDISE (PREDicteurs Individuels, Sociaux et Environnementaux) Study JOURNAL OF NUTRITION, 2021. DOI 10.1093/JN/NXAB042

Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic Acid NUTRIENTS, 2021. DOI 10.3390/NU13082617

Individuals with self-determined motivation for eating have better overall diet quality: Results from the PREDISE study APPETITE, 2021. DOI 10.1016/J.APPET.2021.105426

A Systematic Review and Recommendations Around Frameworks for Evaluating Scientific Validity in Nutritional Genomics FRONTIERS IN NUTRITION, 2021. DOI 10.3389/FNUT.2021.789215

Liking for foods high in salt and fat is associated with a lower diet quality but liking for foods high in sugar is not - Results from the PREDISE study FOOD QUALITY AND PREFERENCE, 2021. DOI 10.1016/J.FOODQUAL.2020.104073

Salmon peptides limit obesity-associated metabolic disorders by modulating a gut-liver axis in vitamin D-deficient mice OBESITY, 2021. DOI 10.1002/OBY.23244