Michèle Desjardins

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche sur le cancer
• Centre thématique de recherche en neurosciences

Financements des 2 dernières années

• Alexandre Cléroux Cuillerier, Doctorat en physique
• Benjamin Trudel, Maîtrise en biophotonique - avec mémoire
• Édouard Thiffault, Maîtrise en physique - physique médicale - avec mémoire
• Francis Bernard, Maîtrise en physique - physique médicale - avec mémoire
• Francis Bernard, Doctorat en physique
• Gérémy Michaud, Maîtrise en physique - physique médicale - avec mémoire
• Jérémie Guilbert, Maîtrise en physique - avec mémoire
• Jérémie Guilbert, Doctorat en physique
• Pierre Girard-Collins, Doctorat en physique
• Pierre-Luc Larouche, Maîtrise en physique - avec mémoire
• Simon Drouin, Maîtrise en physique - avec mémoire
• Simon-Olivier Philibert, Maîtrise en physique - avec mémoire
• Vincent St-Arnault, Doctorat en physique

Encadrements des 5 dernières années

• Anaïs Parrot, Maîtrise en physique - physique médicale - avec mémoire
• Antoine Daigle, Maîtrise en biophotonique - avec mémoire
• François Gaudreault, Maîtrise en physique - physique médicale - avec mémoire
• Frédéric Dion, Maîtrise en physique - physique médicale - avec mémoire
• Frédérique Larose, Maîtrise en physique - physique médicale - avec mémoire
• Gabrielle Germain, Maîtrise en physique - physique médicale - avec mémoire
• Jean-Philippe Lévesque, Maîtrise en physique - physique médicale - avec mémoire
• Jordan Charest, Maîtrise en physique - avec mémoire
• Micaël Carrier, Doctorat en neurosciences
• Pierre Girard-Collins, Maîtrise en physique - avec mémoire
• Vincent Chouinard, Maîtrise en physique - avec mémoire
• Vincent St-Arnault, Maîtrise en physique - physique médicale - avec mémoire

Travaux de recherche des 5 dernières années

Investigation of Poststroke Depression Following a Nucleus Accumbens Infarct in Mice STROKE, 2025. DOI 10.1161/STROKEAHA.125.050839

Quantitative polarization microscopy as a potential tool for quantification of mechanical stresses within 3D matrices ACTA BIOMATERIALIA, 2025. DOI 10.1016/J.ACTBIO.2025.04.052

Microvascular structure variability explains variance in fMRI functional connectivity BRAIN STRUCTURE & FUNCTION, 2025. DOI 10.1007/S00429-025-02899-4

Comparison of compartmental analytical Blood-Oxygen-Level-Dependent functional Magnetic Resonance Imaging models against Monte Carlo simulations performed over cortical micro-angiograms NMR IN BIOMEDICINE, 2024. DOI 10.1002/NBM.5252

Microvascular structure variability explains variance in fMRI functional connectivity bioRxiv, 2024. Gaudreault, F., Desjardins, M.. DOI 10.1101/2024.03.22.585979

Bone marrow-derived myeloid cells transiently colonize the brain during postnatal development and interact with glutamatergic synapses iScience, 2024. Carrier, M., Robert, M.-È., St-Pierre, M.-K., Ibáñez, F.G., Gonçalves de Andrade, E., Laroche, A., Picard, K., Vecchiarelli, H.A., Savage, J.C., Boilard, É., Desjardins, M., Tremblay, M.-È.. DOI 10.1016/j.isci.2024.110037

Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge Brain, Behavior, and Immunity, 2024. Carrier, M., Hui, C.W., Watters, V., Šimončičová, E., Picard, K., González Ibáñez, F., Vernoux, N., Droit, A., Desjardins, M., Tremblay, M.-È.. DOI 10.1016/j.bbi.2023.11.025

Comparison of compartmental analytical BOLD fMRI models against Monte Carlo simulations performed over cortical micro-angiograms bioRxiv, 2024. Charest, J., Walsh, M., Genois, É., Sévigny, E., Schwarz, P.-O., Gagnon, L., Desjardins, M.. DOI 10.1101/2024.03.06.583728

Bone Marrow-Derived Myeloid Cells Colonize the Brain Parenchyma During Postnatal Development and Interact with Synapses in Mice Under Normal Physiological Conditions SSRN, 2023. Carrier, M., Robert, M.-È., St-Pierre, M.-K., Ibáñez, F.G., de Andrade, E.G., Savage, J.C., Desjardins, M., Tremblay, M.-È.. DOI 10.2139/ssrn.4608531

In Vivo Imaging of Neuronal Activity and Blood Vessels in AAV-Injected Mice Optics and the Brain in Proceedings Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023, 2023. Parrot, A., Guilbert, J., Girard-Collins, P., Desjardins, M.. DOI 10.1364/BRAIN.2023.BM4B.5

Movement correction method for laser speckle contrast imaging of cerebral blood flow in cranial windows in rodents JOURNAL OF BIOPHOTONICS, 2022. DOI 10.1002/JBIO.202100218

The implication of a diversity of non-neuronal cells in disorders affecting brain networks Frontiers in Cellular Neuroscience, 2022. Carrier, M., Dolhan, K., Bobotis, B.C., Desjardins, M., Tremblay, M.E.. DOI 10.3389/fncel.2022.1015556

Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2022. DOI 10.1177/0271678X20928011

Baseline oxygen consumption decreases with cortical depth PLoS Biology, 2022. Mächler, P., Fomin-Thunemann, N., Thunemann, M., Sætra, M.J., Desjardins, M., Kılıç, K., Amra, L.N., Martin, E.A., Chen, I.A., Şencan-Eğilmez, I., Li, B., Saisan, P., Jiang, J.X., Cheng, Q., Weldy, K.L., Boas, D.A., Buxton, R.B., Einevoll, G.T., Dale, A.M., Sakadžić, S., Devor, A.. DOI 10.1371/journal.pbio.3001440

Toward an integrative neurovascular framework for studying brain networks NEUROPHOTONICS, 2022. DOI 10.1117/1.NPH.9.3.032211

Measuring impact of oxygen on radiotherapy treatment using finite element method on mouse's vascular network using numerous surviving models compared to the linear quadratic model MEDICAL PHYSICS, 2022.

Microscopic Quantification of Oxygen Consumption across Cortical Layers 2021. Philipp Mächler, Natalie Fomin-Thunemann, Martin Thunemann, Marte Julie Sætra, Michèle Desjardins, Kıvılcım Kılıç, Ikbal Şencan, Baoqiang Li, Payam Saisan, Qun Cheng, Kimberly L. Weldy, David A. Boas, Richard B. Buxton, Gaute T. Einevoll, Anders M. Dale, Sava Sakadžić, Anna Devor. DOI 10.1101/2021.10.13.464176

A suite of neurophotonic tools to underpin the contribution of internal brain states in fMRI CURRENT OPINION IN BIOMEDICAL ENGINEERING, 2021. DOI 10.1016/J.COBME.2021.100273

Modeling of vascular space occupancy and BOLD functional MRI from first principles using real microvascular angiograms MAGNETIC RESONANCE IN MEDICINE, 2021. DOI 10.1002/MRM.28429

Structural and Functional Features of Developing Brain Capillaries, and Their Alteration in Schizophrenia FRONTIERS IN CELLULAR NEUROSCIENCE, 2021. DOI 10.3389/FNCEL.2020.595002

Interactive database for 2-photon-based oxygen phosphorescence lifetime imaging data Optics InfoBase Conference Papers, 2021. Amra, L., Mächler, P., Fomin-Thunemann, N., Desjardins, M., Kilic, K., Saisan, P., Sencan, I., Li, B., Sakadžić, S., Devor, A., Thunemann, M..

Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice FRONTIERS IN PHYSIOLOGY, 2021. DOI 10.3389/FPHYS.2020.612678