Paul Toren

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche sur le cancer

Financements des 2 dernières années

• Geneviève Trépanier, Doctorat en microbiologie-immunologie
• Geneviève Trépanier, Maîtrise en biologie cellulaire et moléculaire - avec mémoire

Encadrements des 5 dernières années

• Samuel Tremblay, Maîtrise en épidémiologie - épidémiologie clinique - avec mémoire
• Typhaine Gris, Stage postdoctoral en médecine

Travaux de recherche des 5 dernières années

Beyond the label ‘high‐grade’: histological heterogeneity as a prognostic marker in Ta non‐muscle‐invasive bladder cancer BJU International, 2026. Francis Simard, Marie‐Maxime Lacombe, David Simonyan, Charles‐Antoine Garneau, Edouard Cazes, Coralie Deschênes, Sophie Morin, Paul Toren, Alain Bergeron, Alexandre Zlotta, Wassim Kassouf, Chantal Atallah, Michele Lodde. DOI 10.1111/bju.70522

Neoadjuvant Immunotherapy in Bladder Cancer: Ushering in a New Era of Treatment-A Systematic Review of Current Evidence. European urology open science, 2025. Suartz CV, de Lima RD, de Almeida LS, Liebl B, Lopes RI, Branquinho Reis GB, Henry Sant'Anna PV, Faris de Campos VD, Mota JM, Lima Aguiar Melão BV, Fradet V. DOI 10.1016/j.euros.2025.07.010

Ex vivo culture to evaluate dynamic changes in the tumor microenvironment following durvalumab treatment 2025. Gris T, Shore H, Ménard C, Lacombe L, Fradet V, Pouliot F, Lodde M, Fradet Y, Toren P. DOI 10.21203/rs.3.rs-7180379/v1

Podium Session 4: Oncology–Bladder, Kidney, Other : Sunday, June 29, 2025 • 8:45–9:45 Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2025. Mousa A, Chavarriaga J, Burrafato Z, Kaushal S, Atenafu E, Langleben C, Anson-Cartwright L, Warde P, Chung P, Bedard P, Jiang D, O’Malley M, Bukavina L.

Poster Session 3: Oncology–Bladder : Saturday, June 28, 2025 • 16:00–17:30 Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2025. Laaraj J, Racine H, Tourigny R, Lachance G, Koné P, Fadel J, Toren P, Bergeron A, Fradet Y, Robitaille K, Fradet V, Reznik G, Macklin C, Gleave M, Kassouf W.

Urachal Carcinomas: A Comprehensive Systematic Review and Meta-analysis. International braz j urol : official journal of the Brazilian Society of Urology, 2025. Suartz CV, Martinez LM, Silvestre MHL, Lima RD, Brito PHS, Galhardo KA, Lopes RI, Moraes VHS, Moraes CMT, Covatti L, Azevedo MFD, Almeida LS, Setoue DND, Braz NDSF, Bessa J Júnior, Korkes F, Reis LO, Leite KRM, Nahas WC, Toren P, Ribeiro-Filho LA. DOI 10.1590/s1677-5538.ibju.2024.0665

Comparing open and video endoscopic lymphadenectomy for penile cancer: a systematic review and meta-analysis of prospective studies. BJU international, 2025. Suartz CV, de Lima RD, Abud LR, Brito PHS, Galhardo KA, Talizin TB, Salazar AL, Korkes F, Guglielmetti G, de Cássio Zequi S, Ribeiro-Filho LA, Toren P, Lodde M. DOI 10.1111/bju.16661

Reevaluating the Role of Extended Pelvic Lymphadenectomy in Muscle-Invasive Bladder Cancer: Insights From SWOG S1011 and LEA AB 25-02 Trials. Clinical genitourinary cancer, 2024. Suartz CV, Fradet V, Toren P, Ribeiro-Filho LA, Chade D, Korkes F. DOI 10.1016/j.clgc.2024.102249

Artificial intelligence for predicting response to neoadjuvant chemotherapy for bladder cancer A comprehensive systematic review and meta-analysis. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2024. Suartz CV, Martinez LM, Cordeiro MD, Flores HA, Kodama S, Cardili L, Mota JM, Coelho FMA, de Bessa Junior J, Camargo CP, Teoh JY, Shariat SF, Ribeiro-Filho LA. DOI 10.5489/cuaj.8681

The Neutrophil-to-Lymphocyte Ratio as a Biomarker in Metastatic Castrate-Sensitive Prostate Cancer Patients Treated with Abiraterone Acetate Société Internationale d’Urologie Journal, 2024. Caio Vinícius Suartz, Marie-Laurence Roy, Paul Toren. DOI 10.3390/siuj5040044

Circulating Basophils as a Prognostic Marker for Response to Bacillus Calmette-Guérin Clinical Genitourinary Cancer, 2024. Geneviève Trépanier, Timo Nykopp, Raphaëlla Rosebush-Mercier, Typhaine Gris, Jonathan Fadel, Peter C. Black, Paul Toren. DOI 10.1016/j.clgc.2023.12.004

Honing the Hunt: A Comprehensive Review of Cell-free Tumor DNA to Predict Neoadjuvant Therapy Efficacy in Bladder Cancer. Clinical genitourinary cancer, 2024. Suartz CV, Martinez LM, Cordeiro MD, Botelho LAA, Gallutti FP, Mota JM, Leite KRM, Toren P, Nahas WC, Ribeiro-Filho LA. DOI 10.1016/j.clgc.2024.102087

The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression. The Journal of clinical investigation, 2024. Lafront C, Germain L, Campolina-Silva GH, Weidmann C, Berthiaume L, Hovington H, Brisson H, Jobin C, Frégeau-Proulx L, Cotau R, Gonthier K, Audet-Walsh É. DOI 10.1172/jci170809

Predicting individual outcomes after radical cystectomy in urothelial variants with Cancer of the Bladder Risk Assessment (COBRA) score. World journal of urology, 2024. Suartz CV, Cordeiro MD, Botelho LAA, Gallucci FP, Cho DH, de Arruda Pessoa F, da Silva FR, Costa MSS, Cardili L, Audenet F, Mota JM, Toren P, Ribeiro-Filho LA. DOI 10.1007/s00345-024-04798-5

A phase IIb randomized placebo-controlled trial testing the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation. Communications medicine, 2024. Robitaille K, Guertin MH, Jamshidi A, Xu HW, Hovington H, Pelletier JF, Beaudoin L, Gevariya N, Lacombe L, Tiguert R, Caumartin Y, Dujardin T, Fradet V. DOI 10.1038/s43856-024-00456-4

The sex gap in bladder cancer survival — a missing link in bladder cancer care? Nature Reviews Urology, 2024. Paul Toren, Anna Wilkins, Keval Patel, Amy Burley, Typhaine Gris, Roger Kockelbergh, Taha Lodhi, Ananya Choudhury, Richard T. Bryan. DOI 10.1038/s41585-023-00806-2

Salvage therapy for BCG failure with intravesical sequential gemcitabine and docetaxel in patients with recurrent NMIBC. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2024. Garneau CA, Marcotte N, Lacombe L, Fradet Y, Fradet V, Pouliot F, Toren P, Lodde M. DOI 10.5489/cuaj.8341

Effects of omega‐3 supplementation on psychological symptoms in men with prostate cancer: Secondary analysis of a double‐blind placebo‐controlled randomized trial Cancer Medicine, 2023. Josée Savard, Hanane Moussa, Jean‐François Pelletier, Pierre Julien, Louis Lacombe, Rabi Tiguert, Yves Caumartin, Thierry Dujardin, Paul Toren, Frédéric Pouliot, Michele Lodde, Yves Fradet, Karine Robitaille, Vincent Fradet. DOI 10.1002/cam4.6598

NS-AUA 2023 Annual Meeting Abstracts - Oncology - Bladder, Renal, Testes. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2023. DOI 10.5489/cuaj.8577

High infiltration of CD209⁺ dendritic cells and CD163⁺ macrophages in the peritumor area of prostate cancer is predictive of late adverse outcomes. Frontiers in immunology, 2023. Molina OE, LaRue H, Simonyan D, Hovington H, Têtu B, Fradet V, Lacombe L, Toren P, Bergeron A, Fradet Y. DOI 10.3389/fimmu.2023.1205266

CUA 2023 Annual Meeting Abstracts - Poster Session 9: Oncology - Prostate (Part 2) Sunday, June 25, 2023 • 7:00-8:30. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2023. DOI 10.5489/cuaj.8417

Data from Serum Sex Steroids as Prognostic Biomarkers in Patients Receiving Androgen Deprivation Therapy for Recurrent Prostate Cancer: A <i>Post Hoc</i> Analysis of the PR.7 Trial 2023. Paul Toren, Azik Hoffman, Keyue Ding, France-Hélène Joncas, Véronique Turcotte, Patrick Caron, Frédéric Pouliot, Yves Fradet, Éric Lévesque, Chantal Guillemette, Laurence Klotz. DOI 10.1158/1078-0432.c.6529157.v1

Supplementary Figures 1-3, Supplementary Tables 1-5 from Serum Sex Steroids as Prognostic Biomarkers in Patients Receiving Androgen Deprivation Therapy for Recurrent Prostate Cancer: A <i>Post Hoc</i> Analysis of the PR.7 Trial 2023. Paul Toren, Azik Hoffman, Keyue Ding, France-Hélène Joncas, Véronique Turcotte, Patrick Caron, Frédéric Pouliot, Yves Fradet, Éric Lévesque, Chantal Guillemette, Laurence Klotz. DOI 10.1158/1078-0432.22475735.v1

Effects of Concentrated Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation on Quality of Life after Radical Prostatectomy: A Phase II Randomized Placebo-Controlled Trial (RCT-EPA). Nutrients, 2023. Moussa H, Robitaille K, Pelletier JF, Tourigny R, Fradet Y, Lacombe L, Toren P, Lodde M, Tiguert R, Dujardin T, Caumartin Y, Duchesne T, Julien P, Fradet V. DOI 10.3390/nu15061369

Association des Urologues du Québec Congrès Annuel 2022 - Résumés. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2022. DOI 10.5489/cuaj.8204

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation. NAR cancer, 2022. Lelong EIJ, Khelifi G, Adjibade P, Joncas FH, Grenier St-Sauveur V, Paquette V, Gris T, Zoubeidi A, Audet-Walsh E, Lambert JP, Toren P, Mazroui R, Hussein SMI. DOI 10.1093/narcan/zcac034

Perception and satisfaction of patients after telemedicine urology consultations: A matched analysis with physicians' perspective. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2022. Turcotte B, Bélanger L, Blais AS, Blouin AC, Bolduc S, Bolduc-Mokhtar A, Bureau M, Caumartin Y, Cloutier J, Deschênes-Rompré MP, Dujardin T, Pouliot F. DOI 10.5489/cuaj.7819

Analysis of sex-based differences to Bacillus Calmette-Guérin for non-muscle invasive bladder cancer. Urologic oncology, 2022. Fadel J, Simonyan D, Fradet V, Lodde M, Lacombe L, Fradet Y, Toren P. DOI 10.1016/j.urolonc.2022.09.024

Extensive Alteration of Androgen Precursor Levels After Castration in Prostate Cancer Patients and Their Association With Active Androgen Level. The Journal of urology, 2022. Rouleau M, Neveu B, Caron P, Morin F, Toren P, Lacombe L, Turcotte V, Lévesque É, Guillemette C, Pouliot F. DOI 10.1097/ju.0000000000002923

Patients' perceptions on active surveillance for the treatment of small renal masses. Urologic oncology, 2022. Charbonneau G, Hudon C, Lavallée LT, Kassouf W, Gaboury I, Toren P, Couture F, Couture F, Foley V, Tétu A, Richard PO. DOI 10.1016/j.urolonc.2022.07.005

Opioid use after uro-oncologic surgeries in time of opioid crisis. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2022. Turcotte B, Jacques E, Tremblay S, Toren P, Caumartin Y, Lodde M. DOI 10.5489/cuaj.7633

Combining Antiandrogens with Immunotherapy for Bladder Cancer Treatment. European urology open science, 2022. Besançon M, Gris T, Joncas FH, Picard V, Bergeron A, Fradet Y, Toren P. DOI 10.1016/j.euros.2022.06.007

Case - Gigantic obstructive calculi in continent urinary diversion. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2022. Fadel J, Akoum N, Lodde M, Toren P. DOI 10.5489/cuaj.7698

CUA 2022 Annual Meeting Abstracts - Poster Session 9: Oncology - Prostate Sunday, June 26, 2022 • 07:30-09:00. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2022. DOI 10.5489/cuaj.7931

CUA 2022 Annual Meeting Abstracts - Poster Session 7: Oncology - Bladder Sunday, June 26, 2022 • 07:30-09:00. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2022. DOI 10.5489/cuaj.7929

Sex steroid modulation of macrophages within the prostate tumor microenvironment. American journal of clinical and experimental urology, 2022. Berrehail Z, Boibessot C, Gris T, Joncas FH, Gaignier F, Guillemette C, Lacombe L, Fradet Y, Toren P.

Effects of omega-3 fatty acids supplementation on perioperative blood loss and complications after radical prostatectomy Clinical Nutrition ESPEN, 2022. Samuel Fradet, Jean-François Pelletier, Narcisse Singbo, Louis Lacombe, Paul Toren, Michele Lodde, Thierry Dujardin, Rabi Tiguert, Yves Fradet, Karine Robitaille, Vincent Fradet. DOI 10.1016/j.clnesp.2021.12.011

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype. Clinical and translational medicine, 2022. Boibessot C, Molina O, Lachance G, Tav C, Champagne A, Neveu B, Pelletier JF, Pouliot F, Fradet V, Bilodeau S, Fradet Y, Bergeron A, Toren P. DOI 10.1002/ctm2.581

Follicle-stimulating hormone (FSH) levels prior to prostatectomy are not related to long-term oncologic or cardiovascular outcomes for men with prostate cancer. Asian journal of andrology, 2022. Kourbanhoussen K, Joncas FH, D Wallis CJ, Hovington H, Dagenais F, Fradet Y, Guillemette C, Lacombe L, Toren P. DOI 10.4103/aja.aja_58_21

Reply by Authors Journal of Urology, 2021. Samuel Tremblay, Lily Summers-Trasiewicz, Frédéric Pouliot, Juanita M. Crook, Keyue Ding, Laurence Klotz, Paul Toren. DOI 10.1097/JU.0000000000001946.03

Résumés AUQ 2021. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021. DOI 10.5489/cuaj.7674

Interpreting Testosterone and Concomitant Prostate Specific Antigen Values during Androgen Deprivation Therapy for Recurrent Prostate Cancer Journal of Urology, 2021. Samuel Tremblay, Lily Summers-Trasiewicz, Frédéric Pouliot, Juanita M. Crook, Keyue Ding, Laurence Klotz, Paul Toren. DOI 10.1097/JU.0000000000001946

¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is accurate for high-grade prostate cancer bone staging when compared to bone scintigraphy. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021. Otis-Chapados S, Goulet CR, Dubois G, Lavallée É, Dujardin T, Fradet Y, Lacombe L, Lodde M, Tiguert R, Toren P, Fradet V, Beauregard JM, Buteau FA, Pouliot F. DOI 10.5489/cuaj.7107

Northeastern Section of the American Urological Association 73rd Annual Meeting Abstracts. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021. DOI 10.5489/cuaj.7599

Using ex vivo culture to assess dynamic phenotype changes in human prostate macrophages following exposure to therapeutic drugs. Scientific reports, 2021. Boibessot C, Joncas FH, Park A, Berrehail Z, Pelletier JF, Gris T, Bergeron A, Toren P. DOI 10.1038/s41598-021-98903-y

Switching Cancers: A Systematic Review Assessing the Role of Androgen Suppressive Therapy in Bladder Cancer European Urology Focus, 2021. Kassim Kourbanhoussen, Catherine McMartin, Michele Lodde, Alexandre Zlotta, Richard T. Bryan, Paul Toren. DOI 10.1016/j.euf.2020.10.002

Androgen receptor and immune cell PD-L1 expression in bladder tumors predicts disease recurrence and survival World Journal of Urology, 2021. Paul Toren, Hervé Brisson, David Simonyan, Hélène Hovington, Louis Lacombe, Alain Bergeron, Yves Fradet. DOI 10.1007/s00345-020-03358-x

Expression of programmed death ligand-1 (PD-L1) in metastatic and postchemotherapy viable testicular germ cell tumors. Urologic oncology, 2021. Al-Hogbani M, Duguay J, Wagner DC, Haferkamp A, Joubert P, Frees S, Rendon R, Power N, Périgny M, Toren P. DOI 10.1016/j.urolonc.2021.02.014

Images - Para-aortic lymphatic ectasia suggestive of testicular cancer retroperitoneal metastasis. Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021. Chahine S, Toren P. DOI 10.5489/cuaj.6677

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation of long non-coding RNAs 2021. Lelong EIJ, Adjibade P, Joncas F, Khelifi G, Grenier VS, Zoubedi A, Lambert J, Toren P, Mazroui R, Hussein SMI. DOI 10.1101/2021.01.05.425492