Philippe Tessier

• Centre de recherche ARThrite
• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche en arthrite

Financements des 2 dernières années

• Mélody Vaillancourt, Doctorat en microbiologie-immunologie
• Mélody Vaillancourt, Maîtrise en microbiologie-immunologie - avec mémoire

Encadrements des 5 dernières années

• Pier-Olivier Leblanc, Maîtrise en microbiologie-immunologie - avec mémoire

Travaux de recherche des 5 dernières années

Early-life microbiota direct an epithelial S100 program required for neonatal immunity Science Translational Medicine, 2026. Nurit P Azouz, Philippe Alex Tessier, Laura Engleman, Sergei I Grivennikov, Lee Denson, Hitesh Deshmukh, Theresa Alenghat, Maggie Lutz, Seika Hashimoto-Hill, Amanda Waddell, Bruce Vallance, Shikha Negi, Taylor Rice. DOI 10.1126/scitranslmed.adx6147

Acquired Neutrophil Dysregulation in Systemic Lupus Erythematosus: A Central Role for Fc gamma Receptor Engagement 2025. Huot S, Fortin PR, Laflamme C, Tessier PA, Pelletier M, Pouliot M. DOI 10.1101/2025.05.19.653336

HUMANIZED ANTI-S100A9 ANTIBODY 2025.

S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation. Journal of immunology (Baltimore, Md. : 1950), 2024. Boucher J, Gilbert C, Bose S, Tessier PA. DOI 10.4049/jimmunol.2300640

The impact of the herbicide glyphosate and its metabolites AMPA and MPA on the metabolism and functions of human blood neutrophils and their sex-dependent effects on reactive oxygen species and CXCL8/IL-8 production. Environmental research, 2024. Pier-olivier Leblanc, Yann Breton, Florence Léveillé, Philippe A Tessier, Martin Pelletier. DOI 10.1016/j.envres.2024.118831

Metabolic regulation of neutrophil functions in homeostasis and diseases. Journal of leukocyte biology, 2024. Pier-olivier Leblanc, Sylvain G Bourgoin, Patrice E Poubelle, Philippe A Tessier, Martin Pelletier. DOI 10.1093/jleuko/qiae025

Systems genetics uncover new loci containing functional gene candidates in<i>Mycobacterium tuberculosis</i>-infected Diversity Outbred mice 2023. Gatti D, Tyler A, Mahoney J, Churchill G, Yener B, Koyuncu D, Gurcan M, Niazi M, Tavolara T, Gower A, Dayao D, McGlone E, Ginese M, Specht A, Beamer G. DOI 10.1101/2023.12.21.572738

Humanized anti-S100A9 antibody and uses thereof 2023.

Immune Cells Release MicroRNA-155 Enriched Extracellular Vesicles That Promote HIV-1 Infection. Cells, 2023. Boucher J, Rousseau A, Boucher C, Subra C, Bazié WW, Hubert A, Bourgeault E, Benmoussa A, Goyer B, Tessier PA, Gilbert C. DOI 10.3390/cells12030466

Acute inflammatory response via neutrophil activation protects against the development of chronic pain. Science translational medicine, 2022. Parisien M, Lima LV, Dagostino C, El-Hachem N, Drury GL, Grant AV, Huising J, Verma V, Meloto CB, Silva JR, Dutra GGS, Markova T, Dang H, Tessier PA, Diatchenko L. DOI 10.1126/scitranslmed.abj9954

HUMANIZED ANTI-S100A9 ANTIBODY AND USES THEREOF 2021.

ANTI-S100A8 FOR TREATING LEUKEMIA 2021.

Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial. The Lancet. Respiratory medicine, 2021. Tardif JC, Bouabdallaoui N, L'Allier PL, Gaudet D, Shah B, Pillinger MH, Lopez-Sendon J, da Luz P, Verret L, Audet S, Dupuis J, Denault A, COLCORONA Investigators. DOI 10.1016/s2213-2600(21)00222-8

Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis. Scientific reports, 2021. Vaillancourt M, Desaulniers P, Paré G, Pagé N, Lachhab A, Kerever A, Julien AS, Amiable N, Pelletier M, Tessier PA, Bessette L, Michou L, Fortin PR, Fernandes MJ. DOI 10.1038/s41598-021-90631-7

Velocity Gradient Separation Reveals a New Extracellular Vesicle Population Enriched in miR-155 and Mitochondrial DNA. Pathogens (Basel, Switzerland), 2021. Vaillancourt M, Hubert A, Subra C, Boucher J, Bazié WW, Vitry J, Berrazouane S, Routy JP, Trottier S, Tremblay C, Jenabian MA, Benmoussa A, Gilbert C. DOI 10.3390/pathogens10050526

Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19 2021. Tardif J, Bouabdallaoui N, L’Allier PL, Gaudet D, Shah B, Pillinger MH, Lopez-Sendon J, da Luz P, Verret L, Audet S, Dupuis J, Denault A, for the COLCORONA Investigators. DOI 10.1101/2021.01.26.21250494