Serge Rivest

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche du CHU de Québec - Université Laval (Reconnu FRQ - secteur santé)
• Centre thématique de recherche en neurosciences

Financements des 2 dernières années

• Lina Lapeyre, Doctorat en microbiologie-immunologie
• Oceane Perrot, Stage postdoctoral en médecine
• Véronique Lévesque, Doctorat en médecine moléculaire

Encadrements des 5 dernières années

• Laura Martínez Drudis, Doctorat en médecine moléculaire
• Majid Ghareghani, Stage postdoctoral en médecine
• Majid Ghareghani, Doctorat en neurobiologie
• Morgan McLaughlin, Maîtrise en neurosciences - avec mémoire
• Pierre-Alexandre Piec, Maîtrise en médecine moléculaire - avec mémoire

Travaux de recherche des 5 dernières années

Reduced Melatonin Levels May Facilitate Glioblastoma Initiation in the Subventricular Zone Expert reviews in molecular medicine, 2022. DOI 10.1017/erm.2022.15

PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis Frontiers in immunology, 2022. DOI 10.3389/fimmu.2022.862316

Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression Brain, behavior, and immunity, 2022. DOI 10.1016/j.bbi.2021.07.016

Structural analysis of the microglia-interneuron interactions in the CA1 hippocampal area of the APP/PS1 mouse model of Alzheimer's disease The Journal of comparative neurology, 2022. DOI 10.1002/cne.25289

Context-dependent transcriptional regulation of microglial proliferation Glia, 2022. DOI 10.1002/glia.24124

Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease Pharmacological reviews, 2022. DOI 10.1124/pharmrev.121.000400

Case Report: Two Families With HPDL Related Neurodegeneration Frontiers in genetics, 2022. DOI 10.3389/fgene.2022.780764

PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system Life science alliance, 2022. DOI 10.26508/lsa.202201467

The Intellicage system provides a reproducible and standardized method to assess behavioral changes in cuprizone-induced demyelination mouse model Behavioural brain research, 2021. DOI 10.1016/j.bbr.2020.113039

Targeting innate immunity to protect and cure Alzheimer's disease: opportunities and pitfalls Molecular psychiatry, 2021. DOI 10.1038/s41380-021-01083-4

Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021. DOI 10.1007/s13311-021-01035-4

Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease Alzheimer's research & therapy, 2021. DOI 10.1186/s13195-020-00747-7

A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy Frontiers in neurology, 2021. DOI 10.3389/fneur.2021.660113

Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021. DOI 10.1007/s13311-020-00998-0

Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner Frontiers in immunology, 2021. DOI 10.3389/fimmu.2021.813536

A founder mutation in the gene in families from Saguenay-Lac-St-Jean region affected by a pyridoxine-dependent epilepsy JIMD reports, 2021. DOI 10.1002/jmd2.12196

Triggering Innate Immune Receptors as New Therapies in Alzheimer's Disease and Multiple Sclerosis Cells, 2021. DOI 10.3390/cells10082164