Sophie Gobeil

• Centre de recherche en infectiologie
• Centre de recherche sur les protéines PROTEO-ULaval

Financements des 2 dernières années

• Christophe Dussault, Maîtrise en biochimie - avec mémoire
• Cyril Fraser-Laflamme, Maîtrise en biochimie - avec mémoire
• Jacob Côté, Maîtrise en informatique - avec mémoire
• Joseph Descarreaux, Maîtrise en biochimie - avec mémoire
• Rose-Marie Boucher, Maîtrise en microbiologie - avec mémoire
• Sabrina Gentil, Maîtrise en biochimie - avec mémoire

Encadrements des 5 dernières années

• Hyerin Kim, Maîtrise en biochimie - avec mémoire

Travaux de recherche des 5 dernières années

Humans and rhesus macaques share maturation pathways of HIV-1 envelope-reactive V3-glycan bnAb lineages Science Translational Medicine, 2026. Bette Korber, Bhavna Hora, Madison Berry, Yue Chen, Nicole Amy Doria-Rose, Katayoun Mansouri, Sravani Venkatayogi, Chuancang Jiang, Rogier Sanders, Priyamvada Acharya, Jared Lindenberger, Juliette Rando, Wilton Bryan Williams, Wenge Ding, Kevin O Saunders, Lorie Marchitto, Jesse Connell, Kshitij Wagh, Matthew Clark, Mitchell Martin, Sophie Gobeil, Seth Rohr, Younghoon Park, John R Mascola, John William Carey, Hui Li, Michael Patrick Hogarty, Chengyan Zhao, Shuyi Wang, Tyler D. Evangelous, Elena E Giorgi, Barton F Haynes, Kevin Wiehe, Samantha Balgobin, Ashwin Nicholas Skelly, George M. Shaw, Beatrice H Hahn, Marit van Gils, Robert Jon Edwards. DOI 10.1126/scitranslmed.aee9864

Author Correction: Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents Nature Communications, 2025. Praveen R. Juvvadi, David Fox, III, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach. DOI 10.1038/s41467-025-61584-6

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition bioRxiv, 2024. Zhang, Q.E., Lindenberger, J., Parsons, R.J., Thakur, B., Parks, R., Park, C.S., Huang, X., Sammour, S., Janowska, K., Spence, T.N., Edwards, R.J., Martin, M., Williams, W.B., Gobeil, S., Montefiori, D.C., Korber, B., Haynes, B.F., Henderson, R., Acharya, P., Saunders, K.. DOI 10.1101/2024.02.12.580004

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice Science Translational Medicine, 2022. Martinez, D.R., Schäfer, A., Gobeil, S., Li, D., De la Cruz, G., Parks, R., Lu, X., Barr, M., Stalls, V., Janowska, K., Beaudoin, E., Manne, K., Mansouri, K., Edwards, R.J., Cronin, K., Yount, B., Anasti, K., Montgomery, S.A., Tang, J., Golding, H., Shen, S., Zhou, T., Kwong, P.D., Graham, B.S., Mascola, J.R., Montefiori, D.C., Alam, S.M., Sempowski, G.D., Khurana, S., Wiehe, K., Saunders, K.O., Acharya, P., Haynes, B.F., Baric, R.S.. DOI 10.1126/scitranslmed.abj7125

Structural diversity of the SARS-CoV-2 Omicron spike Molecular Cell, 2022. Gobeil, S.M.-C., Henderson, R., Stalls, V., Janowska, K., Huang, X., May, A., Speakman, M., Beaudoin, E., Manne, K., Li, D., Parks, R., Barr, M., Deyton, M., Martin, M., Mansouri, K., Edwards, R.J., Eaton, A., Montefiori, D.C., Sempowski, G.D., Saunders, K.O., Wiehe, K., Williams, W., Korber, B., Haynes, B.F., Acharya, P.. DOI 10.1016/j.molcel.2022.03.028

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike Cell Reports, 2022. Stalls, V., Lindenberger, J., Gobeil, S.M.-C., Henderson, R., Parks, R., Barr, M., Deyton, M., Martin, M., Janowska, K., Huang, X., May, A., Speakman, M., Beaudoin, E., Kraft, B., Lu, X., Edwards, R.J., Eaton, A., Montefiori, D.C., Saunders, K.O., Wiehe, K., Haynes, B.F., Acharya, P., Williams, W.B.. DOI 10.1016/j.celrep.2022.111009

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice 2021. David R. Martinez, Alexandra Schaefer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, Maggie Barr, Kartik Manne, Katayoun Mansouri, Robert J. Edwards, Boyd Yount, Kara Anasti, Stephanie A. Montgomery, Shaunna Shen, Tongqing Zhou, Peter D. Kwong, Barney S. Graham, John R. Mascola, David. C. Montefiori, Munir Alam, Gregory D. Sempowski, Kevin Wiehe, Kevin O. Saunders, Priyamvada Acharya, Barton F. Haynes, Ralph S. Baric. DOI 10.1101/2021.04.27.441655

Development of sulfahydantoin derivatives as β-lactamase inhibitors Bioorganic and Medicinal Chemistry Letters, 2021. Paquet-Côté, P.-A., Alejaldre, L., Lapointe Verreault, C., Gobeil, S.M.C., Lamoureux, R., Bédard, L., Normandeau, C.-O., Lemay-St-Denis, C., Pelletier, J.N., Voyer, N.. DOI 10.1016/j.bmcl.2021.127781

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization Cell Host and Microbe, 2021. Weissman, D., Alameh, M.-G., de Silva, T., Collini, P., Hornsby, H., Brown, R., LaBranche, C.C., Edwards, R.J., Sutherland, L., Santra, S., Mansouri, K., Gobeil, S., McDanal, C., Pardi, N., Hengartner, N., Lin, P.J.C., Tam, Y., Shaw, P.A., Lewis, M.G., Boesler, C., Şahin, U., Acharya, P., Haynes, B.F., Korber, B., Montefiori, D.C.. DOI 10.1016/j.chom.2020.11.012

D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction Cell Reports, 2021. Gobeil, S.M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Manne, K., Stalls, V., Kopp, M.F., Henderson, R., Edwards, R.J., Haynes, B.F., Acharya, P.. DOI 10.1016/j.celrep.2020.108630

SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys bioRxiv, 2021. Saunders, K.O., Lee, E., Parks, R., Martinez, D.R., Li, D., Chen, H., Edwards, R.J., Gobeil, S., Barr, M., Mansouri, K., Alam, S.M., Sutherland, L.L., Cai, F., Sanzone, A.M., Berry, M., Manne, K., Kapingidza, A.B., Azoitei, M., Tse, L.V., Scobey, T.D., Spreng, R.L., Rountree, R.W., DeMarco, C.T., Denny, T.N., Woods, C.W., Petzold, E.W., Oguin, T.H., Sempowski, G.D., Gagne, M., Douek, D.C., Tomai, M.A., Fox, C.B., Seder, R., Wiehe, K., Weissman, D., Pardi, N., Acharya, P., Andersen, H., Lewis, M.G., Moore, I.N., Montefiori, D.C., Baric, R.S., Haynes, B.F.. DOI 10.1101/2021.02.17.431492

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics to Design Selective and Nonimmunosuppressive FK506 Analogs mBio, 2021. Gobeil, S.M.-C., Bobay, B.G., Juvvadi, P.R., Christopher Cole, D., Heitman, J., Steinbach, W.J., Venters, R.A., Spicer, L.D.. DOI 10.1128/mBio.03000-21

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity Science, 2021. Gobeil, S.M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Stalls, V., Kopp, M.F., Manne, K., Li, D., Wiehe, K., Saunders, K.O., Edwards, R.J., Korber, B., Haynes, B.F., Henderson, R., Acharya, P.. DOI 10.1126/science.abi6226

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses Nature, 2021. Saunders, K.O., Lee, E., Parks, R., Martinez, D.R., Li, D., Chen, H., Edwards, R.J., Gobeil, S., Barr, M., Mansouri, K., Alam, S.M., Sutherland, L.L., Cai, F., Sanzone, A.M., Berry, M., Manne, K., Bock, K.W., Minai, M., Nagata, B.M., Kapingidza, A.B., Azoitei, M., Tse, L.V., Scobey, T.D., Spreng, R.L., Rountree, R.W., DeMarco, C.T., Denny, T.N., Woods, C.W., Petzold, E.W., Tang, J., Oguin, T.H., Sempowski, G.D., Gagne, M., Douek, D.C., Tomai, M.A., Fox, C.B., Seder, R., Wiehe, K., Weissman, D., Pardi, N., Golding, H., Khurana, S., Acharya, P., Andersen, H., Lewis, M.G., Moore, I.N., Montefiori, D.C., Baric, R.S., Haynes, B.F.. DOI 10.1038/s41586-021-03594-0

Cold sensitivity of the SARS-CoV-2 spike ectodomain Nature Structural and Molecular Biology, 2021. Edwards, R.J., Mansouri, K., Stalls, V., Manne, K., Watts, B., Parks, R., Janowska, K., Gobeil, S.M.C., Kopp, M., Li, D., Lu, X., Mu, Z., Deyton, M., Oguin, T.H., Sprenz, J., Williams, W., Saunders, K.O., Montefiori, D., Sempowski, G.D., Henderson, R., Munir Alam, S., Haynes, B.F., Acharya, P.. DOI 10.1038/s41594-020-00547-5

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity bioRxiv, 2021. Gobeil, S.M.-C., Janowska, K., McDowell, S., Mansouri, K., Parks, R., Stalls, V., Kopp, M.F., Manne, K., Saunders, K., Edwards, R.J., Haynes, B.F., Henderson, R.C., Acharya, P.. DOI 10.1101/2021.03.11.435037

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates bioRxiv, 2021. Li, D., Edwards, R.J., Manne, K., Martinez, D.R., Schäfer, A., Alam, S.M., Wiehe, K., Lu, X., Parks, R., Sutherland, L.L., Oguin, T.H., McDanal, C., Perez, L.G., Mansouri, K., Gobeil, S.M.C., Janowska, K., Stalls, V., Kopp, M., Cai, F., Lee, E., Foulger, A., Hernandez, G.E., Sanzone, A., Tilahun, K., Jiang, C., Tse, L.V., Bock, K.W., Minai, M., Nagata, B.M., Cronin, K., Gee-Lai, V., Deyton, M., Barr, M., Von Holle, T., Macintyre, A.N., Stover, E., Feldman, J., Hauser, B.M., Caradonna, T.M., Scobey, T.D., Moody, M.A., Cain, D.W., DeMarco, C.T., Denny, T.N., Woods, C.W., Petzold, E.W., Schmidt, A.G., Teng, I.-T., Zhou, T., Kwong, P.D., Mascola, J.R., Graham, B.S., Moore, I.N., Seder, R., Andersen, H., Lewis, M.G., Montefiori, D.C., Sempowski, G.D., Baric, R.S., Acharya, P., Haynes, B.F., Saunders, K.O.. DOI 10.1101/2020.12.31.424729

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies Cell, 2021. Li, D., Edwards, R.J., Manne, K., Martinez, D.R., Schäfer, A., Alam, S.M., Wiehe, K., Lu, X., Parks, R., Sutherland, L.L., Oguin, T.H., McDanal, C., Perez, L.G., Mansouri, K., Gobeil, S.M.C., Janowska, K., Stalls, V., Kopp, M., Cai, F., Lee, E., Foulger, A., Hernandez, G.E., Sanzone, A., Tilahun, K., Jiang, C., Tse, L.V., Bock, K.W., Minai, M., Nagata, B.M., Cronin, K., Gee-Lai, V., Deyton, M., Barr, M., Von Holle, T., Macintyre, A.N., Stover, E., Feldman, J., Hauser, B.M., Caradonna, T.M., Scobey, T.D., Rountree, W., Wang, Y., Moody, M.A., Cain, D.W., DeMarco, C.T., Denny, T.N., Woods, C.W., Petzold, E.W., Schmidt, A.G., Teng, I.-T., Zhou, T., Kwong, P.D., Mascola, J.R., Graham, B.S., Moore, I.N., Seder, R., Andersen, H., Lewis, M.G., Montefiori, D.C., Sempowski, G.D., Baric, R.S., Acharya, P., Haynes, B.F., Saunders, K.O.. DOI 10.1016/j.cell.2021.06.021

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies Cell, 2021. Williams, W.B., Meyerhoff, R.R., Edwards, R.J., Li, H., Manne, K., Nicely, N.I., Henderson, R., Zhou, Y., Janowska, K., Mansouri, K., Gobeil, S., Evangelous, T., Hora, B., Berry, M., Abuahmad, A.Y., Sprenz, J., Deyton, M., Stalls, V., Kopp, M., Hsu, A.L., Borgnia, M.J., Stewart-Jones, G.B.E., Lee, M.S., Bronkema, N., Moody, M.A., Wiehe, K., Bradley, T., Alam, S.M., Parks, R.J., Foulger, A., Oguin, T., Sempowski, G.D., Bonsignori, M., LaBranche, C.C., Montefiori, D.C., Seaman, M., Santra, S., Perfect, J., Francica, J.R., Lynn, G.M., Aussedat, B., Walkowicz, W.E., Laga, R., Kelsoe, G., Saunders, K.O., Fera, D., Kwong, P.D., Seder, R.A., Bartesaghi, A., Shaw, G.M., Acharya, P., Haynes, B.F.. DOI 10.1016/j.cell.2021.04.042