Yves De Koninck

• Centre d'optique, photonique et laser
• Centre de recherche CERVO (Affilié à l’Université Laval)
• Centre thématique de recherche en neurosciences

Financements des 2 dernières années

• Andrée-Anne Verreault, Maîtrise en neurosciences - avec mémoire
• Corentin Emilien Soubeiran, Doctorat en biophotonique
• Einer Munoz Pino, Doctorat en neurobiologie
• Félix Desrosiers, Doctorat en santé communautaire
• Jessica Louise Myatt, Stage postdoctoral en médecine
• Joshua Katambwe, Maîtrise en neurosciences - avec mémoire
• Justin Hamel, Doctorat en biophotonique
• Justin Hamel, Maîtrise en biophotonique - avec mémoire
• Justine Major, Maîtrise en biophotonique - avec mémoire
• Mohamad Feshki, Doctorat en génie électrique
• Pauline Larqué, Doctorat en neurosciences
• Xinying Zhang, Stage postdoctoral en médecine
• Yasin Esmaeilou, Doctorat en neurosciences

Encadrements des 5 dernières années

• Alexy Pelletier-Rioux, Maîtrise en biophotonique - avec mémoire
• Axelle Dovonou, Doctorat en neurobiologie
• Dominique Isabel, Maîtrise en neurosciences - avec mémoire
• Farida Hamidou Farida Hamidou, Maîtrise en médecine moléculaire - avec mémoire
• Iason Keramidis, Stage postdoctoral en neurobiologie
• Iason Keramidis, Doctorat en neurobiologie
• Johanna Alonso, Doctorat en neurobiologie
• Jonathan Damblon, Doctorat en neurobiologie
• Julien Bourbonnais, Maîtrise en biophotonique - avec mémoire
• Louison Brochoire, Doctorat en neurosciences
• Olivier Hyacinthus Tsiakaka, Stage postdoctoral en génie électrique
• Philippe Léonard-Dufour, Maîtrise en neurosciences - avec mémoire
• Reza Hazrati, Doctorat en neurobiologie
• Sahara Khademullah, Stage postdoctoral en médecine
• Sahara Khademullah, Recherche postdoctorale en médecine
• Samuel Ferland, Stage postdoctoral en neurobiologie
• Samuel Ferland, Doctorat en neurobiologie
• Susana Soares Lima, Doctorat en neurosciences

Travaux de recherche des 5 dernières années

Deterministic wet etching of aspheric fiber microlenses with tunable conic geometry for tailored optical functionality Nature Communications, 2026. Sanggon Kim, Iason Keramidis, Isabel Plasencia-Fernandez, Johanna Alonso, Louison Brochoire, Cyril Bories, Annie Barbeau, Younes Messaddeq, Yves De Koninck. DOI 10.1038/s41467-026-75331-y

Differential regulation of KCC2 function, trafficking, and degradation by Ca2+-dependent signaling pathways 2026. Marc J. Bergeron, Isabel Plasencia-Fernandez, Annie Barbeau, Noémie Comeau, Martin Cottet, Antoine G. Godin, Yves De Koninck. DOI 10.64898/2026.07.02.736223

A specialized population of hair afferents dedicated to transmitting mechanical itch. Neuron, 2026. Fatima M, Lee H, Cha H, Hor CC, Wang F, Liu J, Damblon J, Zhang W, Qu K, Nagai Y, Dinh A, Wu Z, Ajimal R, Xiong AE, Chai M, Asmar A, Cai W, Zhou X, Balaji A, Pan H, Horwitz L, Tsoi LC, Hu H, Xu XZS, De Koninck Y, Duan B. DOI 10.1016/j.neuron.2026.05.017

Nucleus raphe magnus serotonin neurones bidirectionally control spinal nociceptive transmission in mice. British journal of anaesthesia, 2026. Grivet Z, Verboven A, Aby F, Bouali-Benazzouz R, Dhellemmes T, Perrot E, Beyeler A, Heisler LK, Balia M, Battefeld A, Martin H, Retailleau A, Maingret F, Fioramonti X, Landry M, De Koninck Y, Benazzouz A, Fossat P. DOI 10.1016/j.bja.2026.03.069

Excessive inhibition in the medial prefrontal cortex contributes to cognitive susceptibility in aging. Neurobiology of disease, 2026. Keramidis I, Desrosiers P, Verreault AA, Sansonetti R, Hazrati R, Godin AG, De Koninck Y. DOI 10.1016/j.nbd.2026.107385

Learned spatially varying microscopy model with adaptive point spread functions. Optics express, 2026. Feshki M, Godin AG, De Koninck Y, Gosselin B. DOI 10.1364/oe.586982

Recommendations for the inclusion and study of sex and gender in research Nature Neuroscience, 2026. David P. Finn, Brian E. McGuire, Simon Beggs, Katelynn E. Boerner, Karen D. Davis, Ruth Defrin, Yves De Koninck, Hemakumar Devan, Ryan Donovan, Eleonora Fetter, Herta Flor, Brona M. Fullen, Catherine R. Healy, Edmund Keogh, Rohini Kuner, Miriam Kunz, Rebecca M. Lane, Stefan Lautenbacher, Emeran A. Mayer, Jeffrey S. Mogil, Siobhain M. O’Mahony, Kieran O’Sullivan, Louise Riordan, Michael W. Salter, Francesco Scarlatti, George Shorten, Kathleen A. Sluka, Jennifer N. Stinson, Kevin E. Vowles, Suellen M. Walker, Ipek Yalcin, Michelle Roche. DOI 10.1038/s41593-025-02164-1

Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents. Neuron, 2026. Leduc-Pessah H, McAllister BB, Sinha S, Stokes-Heck S, Nishizawa D, Fan CY, St-Pierre MK, Bradaia A, Defaye M, Burma NE, Damblon J, Muñoz-Pino E, Visser F, Dorion MF, Healy LM, Tang YM, Canet-Pons J, van den Hoogen NJ, Zhang Z, Antunes FTT, Piscopo VEC, Medina M, Fukuda KI, Ichinohe T, Nagashima M, Hayashida M, Johnson E, Agrawal A, Degenhardt L, Martin NG, Zamponi GW, Nelson EC, Altier C, Tremblay ME, Bousman C, Stifani S, De Koninck Y, Ikeda K, Biernaskie J, Trang T. DOI 10.1016/j.neuron.2025.11.018

A neuronal pathway for the supraspinal relay of warm and cool sensation 2026. Xinying Zhang, Farin Bourojeni, Samuel Ferland, Anna McFarlane, Kieran A. Boyle, Madoka Koyanagi, Marie-Eve Paquet, Andrew J. Todd, Junichi Hachisuka, Yves De Koninck, Feng Wang, Artur Kania. DOI 10.64898/2026.01.19.700348

Chronic optogenetic activation of hippocampal CA1 neurons triggers Alzheimer’s disease-like proteomic remodeling iScience, 2025. Iason Keramidis, Martina Samiotaki, Romain Sansonetti, Johanna Alonso, Patrick Desrosiers, Katerina Papanikolopoulou, Yves De Koninck. DOI 10.1016/j.isci.2025.113454

Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use. Pain, 2025. Davis OC, Ferland S, Lorenzo LE, Murray-Lawson C, Shiers S, Yousuf MS, Dedek A, Tsai EC, Vines E, Horton P, Cervantes A, Khan T, Funk G, Dussor G, Godin AG, Ferrini F, De Koninck Y, Hildebrand ME, Price TJ. DOI 10.1097/j.pain.0000000000003700

Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain. Nature communications, 2025. Yousefpour N, Tansley SN, Locke S, Sharif B, Parisien M, Bourojeni FB, Deamond H, Mathur V, Arana NR, Austin JS, Bourassa V, Wang C, Cabana VC, Wong C, Lister KC, Rodrigues R, St-Louis M, Paquet ME, Carroll MC, Andrews-Zwilling Y, Seguela P, Kania A, Yednock T, Mogil JS, De Koninck Y, Diatchenko L, Khoutorsky A, Ribeiro-da-Silva A. DOI 10.1038/s41467-025-59849-1

The gut microbiota promotes pain in fibromyalgia. Neuron, 2025. Cai W, Haddad M, Haddad R, Kesten I, Hoffman T, Laan R, Westfall S, Defaye M, Abdullah NS, Wong C, Brown N, Tansley S, Lister KC, Hooshmandi M, Wang F, Lorenzo LE, Hovhannisyan V, Ho-Tieng D, Kumar V, Sharif B, Thurairajah B, Fan J, Sahar T, Clayton C, Wu N, Zhang J, Bar-Yoseph H, Pitashny M, Krock E, Mogil JS, Prager-Khoutorsky M, Séguéla P, Altier C, King IL, De Koninck Y, Brereton NJB, Gonzalez E, Shir Y, Minerbi A, Khoutorsky A. DOI 10.1016/j.neuron.2025.03.032

Excitability properties of cardiac calbindin neurons: Identifying a unique neuronal population. Heart rhythm, 2025. Lizot G, Bescond J, De Koninck Y, Chahine M, Bois P, Faivre JF, Chatelier A. DOI 10.1016/j.hrthm.2025.04.007

An improved conflict avoidance assay reveals modality-specific differences in pain hypersensitivity across sexes Pain, 2024. Samuel Ferland, Feng Wang, Yves De Koninck, Francesco Ferrini. DOI 10.1097/j.pain.0000000000003132

A Comprehensive Numerical Study on Fiber Optic SERS Probe Design The Journal of Physical Chemistry C, 2024. Sanggon Kim, Orisson Ponce Gomes, Yves De Koninck, Younes Messaddeq. DOI 10.1021/acs.jpcc.3c07618

Plasmon-induced immobilization of xanthene chemosensors toward repurposing as SERS nanotags Surfaces and Interfaces, 2024. Sanggon Kim, Orisson Gomes, Ali Riaz, Mourad Roudjane, Paulo N. Lisboa-Filho, Augusto Batagin-Neto, Younes Messaddeq, Yves De Koninck. DOI 10.1016/j.surfin.2023.103647

Enhancing gold nanoparticle immobilization on thiolated silica: utilizing neutral ligands to achieve maximum surface coverage for improved SERS substrates Journal of Materials Chemistry C, 2024. Orisson P. Gomes, Sanggon Kim, Paulo N. Lisboa-Filho, Augusto Batagin-Neto, Yves De Koninck, Younes Messaddeq. DOI 10.1039/D3TC04577C

Enhanced harm detection following maternal separation: Transgenerational transmission and reversibility by inhaled amiloride Science Advances, 2023. Marco Battaglia, Orlane Rossignol, Louis-Etienne Lorenzo, Jasmin Deguire, Antoine G. Godin, Francesca R. D’Amato, Yves De Koninck. DOI 10.1126/sciadv.adi8750

Chronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer’s disease-like pathology 2023. Iason Keramidis, Martina Samiotaki, Romain Sansonetti, Johanna Alonso, Katerina Papanikolopoulou, Yves De Koninck. DOI 10.1101/2023.09.12.557365

Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects British Journal of Pharmacology, 2023. Marc López‐Cano, Joan Font, Ester Aso, Kristoffer Sahlholm, Gisela Cabré, Jesús Giraldo, Yves De Koninck, Jordi Hernando, Amadeu Llebaria, Víctor Fernández‐Dueñas, Francisco Ciruela. DOI 10.1111/bph.15645

Assessing spontaneous sensory neuron activity usingin vivocalcium imaging 2023. Sonia L Ingram, Kim I Chisholm, Feng Wang, Yves De Koninck, Franziska Denk, George L Goodwin. DOI 10.1101/2023.01.12.523728

Millimetric scale two-photon Bessel-Gauss beam light sheet microscopy with three-axis isotropic resolution using an axicon lens Neurophotonics, 2023. Akitegetse, Cleophace, Charland, Thomas, Quemener, Mireille, Gora, Charles, Rioux, Veronique, Piche, Michel, De Koninck, Yves, Levesque, Martin, Cote, Daniel C.. DOI 10.1117/1.NPH.10.3.035002

Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer's disease mutations Brain, 2023. Keramidis, Iason, Mcallister, Brendan B., Bourbonnais, Julien, Wang, Feng, Isabel, Dominique, Rezaei, Edris, Sansonetti, Romain, Degagne, Phil, Hamel, Justin P., Nazari, Mojtaba, Inayat, Samsoon, Dudley, Jordan C., Barbeau, Annie, Froux, Lionel, Paquet, Marie-Eve, Godin, Antoine G., Mohajerani, Majid H., De Koninck, Yves. DOI 10.1093/BRAIN/AWAD250

We need to talk: The urgent conversation on chronic pain, mental health, prescribing patterns and the opioid crisis Journal of Psychopharmacology, 2023. Battaglia, Marco, Groenewald, Cornelius B., Campbell, Fiona, Scaini, Simona, De Koninck, Yves, Stinson, Jennifer, Quinn, Patrick D.. DOI 10.1177/02698811221144635

Improving flat fluorescence microscopy in scattering tissue through deep learning strategies Optics Express, 2023. Feshki, Mohamad, Martel, Sylvain, De Koninck, Yves, Gosselin, Benoit. DOI 10.1364/OE.489677

Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain Cell Reports, 2023. Noosha Yousefpour, Samantha Locke, Haley Deamond, Chengyang Wang, Lucas Marques, Manon St-Louis, Johanne Ouellette, Arkady Khoutorsky, Yves De Koninck, Alfredo Ribeiro-da-Silva. DOI 10.1016/j.celrep.2023.112010

Distribution of acid-sensing ion channel subunits in human sensory neurons contrasts with that in rodents Brain Communications, 2022. Melina Papalampropoulou-Tsiridou, Stephanie Shiers, Feng Wang, Antoine G Godin, Theodore J Price, Yves De Koninck. DOI 10.1093/braincomms/fcac256

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain Brain, 2022. Annemarie Dedek, Jian Xu, Louis-Étienne Lorenzo, Antoine G Godin, Chaya M Kandegedara, Geneviève Glavina, Jeffrey A Landrigan, Paul J Lombroso, Yves De Koninck, Eve C Tsai, Michael E Hildebrand. DOI 10.1093/brain/awab408

For a structured response to the psychosocial consequences of the restrictive measures imposed by the global COVID-19 health pandemic: the MAVIPAN longitudinal prospective cohort study protocol BMJ Open, 2022. Annie LeBlanc, Marie Baron, Patrick Blouin, George Tarabulsy, Francois Routhier, Catherine Mercier, Jean-Pierre Despres, Marc Hébert, Yves De Koninck, Caroline Cellard, Delphine Collin-Vézina, Nancy Côté, Émilie Dionne, Richard Fleet, Marie-Hélène Gagné, Maripier Isabelle, Lily Lessard, Matthew Menear, Chantal Merette, Marie-Christine Ouellet, Marc-André Roy, Marie-Christine Saint-Jacques, Claudia Savard. DOI 10.1136/bmjopen-2021-048749

The Canadian Brain Research Strategy: A Focus on Early Career Researchers Canadian Journal of Neurological Sciences, 2022. Menard, C., Siddiqui, T.J., Sargin, D., Lawson, A., De Koninck, Y., Illes, J.. DOI 10.1017/cjn.2021.81

mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation Journal of Clinical Investigation, 2022. Wong, C., Barkai, O., Wang, F., Perez, C.T., Lev, S., Cai, W., Tansley, S., Yousefpour, N., Hooshmandi, M., Lister, K.C., Latif, M., Claudio Cuello, A., Prager-Khoutorsky, M., Mogil, J.S., Seguela, P., De Koninck, Y., Ribeiro-Da-Silva, A., Binshtok, A.M., Khoutorsky, A.. DOI 10.1172/JCI152635

A novel assessment of fine-motor function reveals early hindlimb and detectable forelimb deficits in an experimental model of ALS Scientific Reports, 2022. Khademullah, C. Sahara, De Koninck, Yves. DOI 10.1038/S41598-022-20333-1

Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain Science Advances, 2022. Aby, F., Lorenzo, L.-E., Grivet, Z., Bouali-Benazzouz, R., Martin, H., Valerio, S., Whitestone, S., Isabel, D., Idi, W., Bouchatta, O., De Deurwaerdere, P., Godin, A.G., Herry, C., Fioramonti, X., Landry, M., De Koninck, Y., Fossat, P.. DOI 10.1126/sciadv.abo0689

Microglia-mediated degradation of perineuronal nets promotes pain Science, 2022. Tansley, S., Gu, N., Guzmán, A.U., Cai, W., Wong, C., Lister, K.C., Muñoz-Pino, E., Yousefpour, N., Roome, R.B., Heal, J., Wu, N., Castonguay, A., Lean, G., Muir, E.M., Kania, A., Prager-Khoutorsky, M., Zhang, J., Gkogkas, C.G., Fawcett, J.W., Diatchenko, L., Ribeiro-Da-Silva, A., De Koninck, Y., Mogil, J.S., Khoutorsky, A.. DOI 10.1126/science.abl6773

A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models Journal of Neuroscience, 2022. Paige, C., Plasencia-Fernandez, I., Kume, M., Papalampropoulou-Tsiridou, M., Lorenzo, L.-E., David, E.T., He, L., Mejia, G.L., Driskill, C., Ferrini, F., Feldhaus, A.L., Garcia-Martinez, L.F., Akopian, A.N., De Koninck, Y., Dussor, G., Price, T.J.. DOI 10.1523/JNEUROSCI.1137-21.2022

Editorial: Shedding Light on the Nervous System: Progress in Neurophotonics Research Frontiers in Neural Circuits, 2022. Ruthazer, E.S., Béïque, J.-C., De Koninck, Y.. DOI 10.3389/fncir.2022.901376

A Wireless Electro-Optic Platform for Multimodal Electrophysiology and Optogenetics in Freely Moving Rodents Frontiers in Neuroscience, 2021. Bilodeau, G., Gagnon-Turcotte, G., Gagnon, L.L., Keramidis, I., Timofeev, I., De Koninck, Y., Ethier, C., Gosselin, B.. DOI 10.3389/fnins.2021.718478

An Indigenous Lens on Priorities for the Canadian Brain Research Strategy Canadian Journal of Neurological Sciences, 2021. Perreault, M.L., King, M., Gabel, C., Mushquash, C.J., De Koninck, Y., Lawson, A., Marra, C., Menard, C., Young, J.Z., Illes, J.. DOI 10.1017/cjn.2021.501

The International Brain Initiative: enabling collaborative science The Lancet Neurology, 2021. Quaglio, Gianluca, Toia, Patrizia, Moser, Edvard I., Karapiperis, Theodoros, Amunts, Katrin, Okabe, Shigeo, Poo, Mu-ming, Rah, Jong-Cheol, De Koninck, Yves, Ngai, John, Richards, Linda, Bjaalie, Jan G.. DOI 10.1016/S1474-4422(21)00389-6